Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes.

By J. Pickup, G. Chusney, Stephen M. Thomas, D. Burt. Life Science, 2000

627 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Genetics

View Paper: https://www.semanticscholar.org/paper/6fb6caee7d13f36c128603db7365bede423658a0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. Ralph DeFronzo
2. B. K. Pedersen
3. Nur Samsu
4. M. Febbraio
5. I. Tabas
6. K. Bornfeldt

In Epidemiology

1. B. K. Pedersen
2. M. Febbraio
3. Ralph DeFronzo
4. C. Fischer
5. J. Sullivan
6. M. Liesa
7. G. Frühbeck
8. Nur Samsu

In Genetics

1. Ralph DeFronzo
2. J. Sullivan
3. B. K. Pedersen
4. C. Keller
5. Nur Samsu
6. A. Elmarakby

Citations in the corpus

• The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. (2001, background): “Although the mechanisms of TNF-mediated insulin resistance are only incompletely understood, TNF-a is a potentially attractive target for pharmacological intervention aimed at protecting against obesity-induced insulin resistance (124, 169).”
• Oxidative Stress in Obesity: A Critical Component in Human Diseases (2014, background): “Interestingly, serum TNF-α levels are also higher in type 2 diabetes patients [90].”
• Mitochondrial dynamics in mammalian health and disease. (2009, background): “Interleukin-6 is produced by several cell types including macrophages, adipose cells, and skeletal muscle, and circulating levels are increased in type 2 diabetes (237, 242), thereby interfering with insulin signaling in muscle and hepatic cells (171, 250) and causing hepatic and muscle insulin resi”
• Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy. (2012, background): “Serum IL-6 levels are also significantly greater in diabetic patients with overt proteinuria compared to normoalbuminuric and microalbuminuric patients [110,111].”
• Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “In humans with T2DM, IL-6 levels are increased and correlate with the severity of glucose intolerance (164) and with the severity of inflammation, as indicated by the highly sensitive C-reactive protein (CRP) serum concentration (165).”
• Interleukin-6 induces cellular insulin resistance in hepatocytes. (2002, background): “Of these proinflammatory cytokines, IL-6 has been shown to have the strongest correlation with insulin resistance and type 2 diabetes (5,9,10).”
• IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. (2003, background): “A number of epidemiological studies have shown increased levels of both TNF- and IL-6 in aging (4), in obese individuals (2), and in patients with type 2 diabetes (13, 17, 24, 34).”
• Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment (2021, background): “Inflammatory factors, such as IL-6, tumor necrosis factor (TNF-α), TGF-β1, and IL-18 are elevated in blood [52] and have been shown to be involved in the development and progression of DN [53].”
• Muscle‐derived interleukin‐6: possible biological effects (2001, background): “Interestingly, in the study by Pickup et al. (2000) the basal production of IL-6 in cultured blood cells from diabetics was depressed compared with blood from nondiabetics.”