Oxidative Stress in Obesity: A Critical Component in Human Diseases
By L. Marseglia, S. Manti, G. D'angelo, A. Nicotera, E. Parisi, Gabriella Di Rosa, E. Gitto, T. Arrigo. International Journal of Molecular Sciences, 2014
877 citations recorded by the source corpus.
Obesity, a social problem worldwide, is characterized by an increase in body weight that results in excessive fat accumulation. Obesity is a major cause of morbidity and mortality and leads to several diseases, including metabolic syndrome, diabetes mellitus, cardiovascular, fatty liver diseases, and cancer. Growing evidence allows us to understand the critical role of adipose tissue in controlling the physic-pathological mechanisms of obesity and related comorbidities. Recently, adipose tissue, especially in the visceral compartment, has been considered not only as a simple energy depository tissue, but also as an active endocrine organ releasing a variety of biologically active molecules known as adipocytokines or adipokines. Based on the complex interplay between adipokines, obesity is also characterized by chronic low grade inflammation with permanently increased oxidative stress (OS). Over-expression of oxidative stress damages cellular structures together with under-production of anti-oxidant mechanisms, leading to the development of obesity-related complications. The aim of this review is to summarize what is known in the relationship between OS in obesity and obesity-related diseases.
Subfields: Epidemiology, Nutrition and Dietetics, Physiology
View Paper: https://www.semanticscholar.org/paper/ea67a645018436e2bff40da3f5e929f0243daa0d
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Citations in the corpus
- The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017, neutral): “First, what types of pro-angiogenic mechanisms are in effect either simultaneously or sequentially (and in which order) during the expansion of AT? Second, how do we properly define the stages of AT expansion and further identify when angiogenesis is appropriate and when it is pathologic? Third, can”
- A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health. (2018, background): “Antioxidant as well as antiinflammatory activities of carotenoids or their derivatives might also be of relevance in regard to obesity, as obesity entails the development of oxidative stress and inflammation in adipose tissue [425, 426].”
- Mechanisms of Oxidative Stress in Metabolic Syndrome (2023, background): “This causes an increase in the production of cytokines such as TNF-α, which in turn generates more ROS in the tissues and worsens lipid peroxidation [55].”