Muscle‐derived interleukin‐6: possible biological effects

By B. K. Pedersen, A. Steensberg, P. Schjerling. Journal of Physiology, 2001

613 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/3578400bcb218f99366cab324403a4718b7f5657

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Citations in the corpus

Age-related inflammatory cytokines and disease. (2003, background): “Current research shows that pure concentric exercise without any muscle damage also induces marked production of IL-6 and that IL-6 is produced as a direct consequence of contraction [144].”
Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles (2002, background): “It has been well demonstrated that the plasma concentration of interleukin-6 (IL-6) increases up to 100-fold during muscular exercise (1, 2).”
The anti-inflammatory effect of exercise. (2005, background): “The cytokine response to exercise differs from that elicited by severe infections (33, 98, 100, 138).”
Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans (2003, background): “Exercise induces numerous immunological changes (6), and it has recently been observed that working muscles produce (7) and release (8) large amounts of IL-6 into the systemic circulation (9).”
Insulin resistance and chronic cardiovascular inflammatory syndrome. (2003, neutral): “It has been suggested that depleted glycogen content or an energy crisis in the contracting muscle, rather than muscle damage, may be one stimulus for the IL-6 release (154).”
Interleukin-6 induces cellular insulin resistance in hepatocytes. (2002, background): “Exercise also increases circulating IL-6, occuring through increased production by the muscle (13,14).”
Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases (2015, background): “Exercise training induces anti-inflammation and specifically suppresses TNF production (Pedersen et al., 2001; Febbraio and Pedersen, 2002).”
IL-6 signal transduction and its physiological roles: the signal orchestration model. (2003, background): “As the source of IL-6, not only immune cells, but a variety of other cell types, such as muscle cells (Pedersen et al. 2001), adipocytes (Yudkin et al.”
Evidence for prescribing exercise as therapy in chronic disease (2006, background): “Physical training appears to induce anti-inflammation and specifically inhibit TNF production (Pedersen et al., 2001; Febbraio & Pedersen, 2002).”
Role of myokines in exercise and metabolism. (2007, background): “This research led to the discovery that exercise provokes an increase in a number of cytokines (58).”