IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans.

By A. Steensberg, C. Fischer, C. Keller, K. Møller, B. K. Pedersen. American Journal of Physiology. Endocrinology and Metabolism, 2003

1,152 citations recorded by the source corpus.

Subfields: Complementary and alternative medicine, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/2a79088c22885cbb731eea06b998fc8cd39861e7

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Citations in the corpus

The anti-inflammatory effect of exercise. (2005, background): “Therefore, IL-6 induces an anti-inflammatory environment by inducing the production of IL-1ra and IL-10, but it also inhibits TNF- production, as suggested by in vitro (37) and animal studies (72, 75).”
Exercise and mental health. (2017, background): “In fact a study of endurance athletes prone to upper respiratory infection, found that IL-10 production was 4 times higher than in athletes that were illness free [68].”
Role of myokines in exercise and metabolism. (2007, background): “The exercise-induced increase in plasma IL-6 is followed by increased circulating levels of well-known anti-inflammatory cytokines such as IL-1ra and IL-10 (48, 50), and infusion of IL-6 to healthy donors mimics the exercise response on IL-1ra and IL-10 and enhances systemic levels of cortisol (70).”
Muscles and their myokines (2011, background): “THE JOURNAL OF EXPERIMENTAL BIOLOGY 341Muscles and their myokines inflammatory effects of IL-6 are also demonstrated by the finding that IL-6 stimulates the production of the classical anti-inflammatory cytokines IL-1ra and IL-10 (Steensberg et al., 2003).”
Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. (2016, positive): “In further support of the role of IL-6 in NK cell redistribution and activation, recombinant human IL-6 infusion has been shown to mimic the acute and transient lymphopenia seen during the recovery from exercise (Steensberg et al., 2003), and stimulation of human NK cells with IL-6 has been shown to”
Immune function in sport and exercise. (2007, background): “In addition, it was recently demonstrated that relatively small increases in plasma levels of IL-6 induce the two anti-inflammatory cytokines IL-1ra and IL-10, together with CRP (50).”
Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View (2013, background): “IL-6 inhibits the release of TNF-α and IL-1 [57] and enhances the circulation levels of anti-inflammatory mediators, such as IL-1Ra, sTNFRs, IL-10, TGF-β, and cortisol [58, 60, 62].”
Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “(Endocrine Reviews 41: 594 – 609, 2020) Graphical Abstract Improves aging skin Promotes endothelial function and revascularization Bone formation Lipolysis Browning Adipose tissue Immune cells Liver Pancreas Hepatic glucose production during exercise Blood vessels Hypertrophy Glucose uptake AMPK My”