The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation.
By G. Frühbeck, J. Gómez-Ambrosi, F. Muruzábal, M. A. Burrell. American Journal of Physiology. Endocrinology and Metabolism, 2001
1,006 citations recorded by the source corpus.
The ability to ensure continuous availability of energy despite highly variable supplies in the environment is a major determinant of the survival of all species. In higher organisms, including mammals, the capacity to efficiently store excess energy as triglycerides in adipocytes, from which stored energy could be rapidly released for use at other sites, was developed. To orchestrate the processes of energy storage and release, highly integrated systems operating on several physiological levels have evolved. The adipocyte is no longer considered a passive bystander, because fat cells actively secrete many members of the cytokine family, such as leptin, tumor necrosis factor-alpha, and interleukin-6, among other cytokine signals, which influence peripheral fuel storage, mobilization, and combustion, as well as energy homeostasis. The existence of a network of adipose tissue signaling pathways, arranged in a hierarchical fashion, constitutes a metabolic repertoire that enables the organism to adapt to a wide range of different metabolic challenges, such as starvation, stress, infection, and short periods of gross energy excess.
Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/5d806ea3d40ae0b9a3b838bc57b2a53ffff2cd5c
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Citations in the corpus
- Adipokines: inflammation and the pleiotropic role of white adipose tissue (2004, background): “This is in addition to the adipocytes’ central role in the deposition and release of fatty acids (Mohamed-Ali et al. 1998; Frühbeck et al. 2001; Trayhurn & Beattie, 2001).”
- Adipose tissue as a buffer for daily lipid flux (2002, result): “We do not wish to ignore other potential links between adipose tissue and insulin resistance, but these have been reviewed thoroughly by other authors [97, 98, 99].”
- Hypoxia and adipose tissue function and dysfunction in obesity. (2013, background): “White adipocytes are major secretory cells, releasing a multiplicity of lipid and protein entities in addition to the stored fatty acids that are mobilized on lipolysis (52, 158, 193, 194).”
- Adiponectin Regulation and Function (2018, positive): “However, over the previous two decades, adipose tissue has been discovered to also be an important endocrine organ, playing a vital role in the regulation of various physiological functions through the secretion of a number of hormones (76, 97, 265, 333).”
- Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “It now is recognized that the adipocyte is a metabolic factory that produces a wide variety of adipocytokines (112).”