Inhibition of histone deacetylase activity by butyrate.

By J. Davie. Journal of NutriLife, 2003

1,384 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6f48fa59effc33ae1acd06d57cad2f3c3ff5df79

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Citations in the corpus

Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents (2015, background): “Short-chain fatty acids, such as sodium butyrate, the byproduct of anaerobic microbial fermentation inside the gastrointestinal tract, have been found to inhibit different classes of HDAC [124].”
Butyrate: A Double-Edged Sword for Health? (2018, background): “A model was proposed that butyrate inhibits the recruitment of HDACs to the promoter by transcription factors, specificity protein 1/specificity protein 3 (Sp1/Sp3), leading to histone hyperacetylation (55).”
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, background): “The most well-known of these is probably butyrate, which acts as a potent inhibitor of HDACs (Candido et al. 1978; Davie 2003).”
Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice (2009, background): “The bioactivities of SB are related to inhibition of class I and class II histone deacetylases (HDACs) (7).”
The Warburg Effect Dictates the Mechanism of Butyrate Mediated Histone Acetylation and Cell Proliferation (2012, background): “Present at high levels (mM) in the lumen, butyrate is the primary energy source for colonocytes (Fleming et al., 1991; Roediger, 1982) and also functions as a histone deacetylase (HDAC) inhibitor [reviewed in (Davie, 2003).”
Gut Microbial Metabolites Fuel Host Antibody Responses. (2016, background): “SCFAs are HDAC inhibitors and, therefore, have the potential to regulate gene expression and cell signaling through regulation of protein acetylation (Davie, 2003).”
Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils. (2011, background): “SCFAs can also act on leukocytes through inhibition of HDAC activity [34].”
The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages (2019, methodology): “We initially treated macrophages with TMP195, an inhibitor of HDAC class IIa (Davie, 2003) that has been used to activate tumor-associated macrophages (Guerriero et al.”
Role of the Microbiota in Immunity and inflammation (2014, background): “Butyrate is well known to regulate gene expression epigenetically by inhibiting histone deacetylases (HDACs) (Davie, 2003), and this property is currently proposed as an underlying mechanism for enhanced Treg generation in the gut.”
Short chain fatty acids in human gut and metabolic health. (2020, neutral): “SCFA may have a versatile role in supporting immune homeostasis (Davie, 2003; McKenzie et al. , 2017; McNabney and Henagan, 2017; Schilderink et al. , 2016).”
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition (2014, background): “In our study, we demonstrate that n-butyrate, a bacterial metabolite found in high abundance in the colon, regulates macrophage function through the inhibition of HDACs. n-Butyrate may behave as a microbial signal to inform the host immune system that the relative levels of n-butyrate–producing bact”
Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates (2014, neutral): “diverse regulatory roles including regulating histone acetylation and signaling through G protein coupled receptors (Bergman, 1990; Brown et al., 2003; Davie, 2003).”