Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils.
By M. Vinolo, H. Rodrigues, E. Hatanaka, F. T. Sato, S. Sampaio, R. Curi. Journal of Nutritional Biochemistry, 2011
650 citations recorded by the source corpus.
Subfields: Cancer Research, Pharmacology, Surgery
View Paper: https://www.semanticscholar.org/paper/b72d80f486e95eea9ddfa36ad7c9125d9f35beac
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Citations in the corpus
- Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body (2021, background): “In this way, the NF-kB pathway, Treg cell suppression, and pro-inflammatory cytokine production by neutrophils and macrophages are inhibited; consequently, the inflammation state is prevented, and an anti-inflammatory effect is produced (91, 92).”
- Microbiota metabolite short chain fatty acids, GCPR, and inflammatory bowel diseases (2016, background): “Furthermore, SCFA could also inhibit pro-inflammatory cytokine production such as TNFa in neutrophils [32].”
- Gut Microbiota and Immune System Interactions (2020, background): “SCFAs have multiple mechanisms of inhibiting inflammation in the gut [25].”
- Short-chain fatty acids: linking diet, the microbiome and immunity (2024, positive): “SCFAs regulate the chemotactic recruitment and antibacterial responses of neutrophils through both HDAC inhibition 78 and GPR43 signalling 79 .”
- Regulation of Inflammation by Short Chain Fatty Acids (2011, background): “This effect can explain, at least in part, the reduction of leukocyte recruitment observed in response to inflammatory stimuli after oral administration of tributyrin [21].”
- Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism (2020, background): “For example, butyrate and propionate reduce the expression of TNF and nitric oxide synthase (NOS) in LPS-induced monocytes [97].”
- The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages (2019, background): “Furthermore, exposure of peripheral blood mononuclear cells such as neutrophils, macrophages, and dendritic cells to SCFAs or other HDAC inhibitors, such as trichostatin (TSA), inhibits inflammatory cytokine production (Chang et al., 2014; Usami et al., 2008; Vinolo et al., 2011a).”
- Short chain fatty acids and its producing organisms: An overlooked therapy for IBD? (2021, background): “Decreased IL10 was observed after LPS-stimulation, as well as a dose-dependent inhibition of cytokine CCL2.”
- Butyrate: A Double-Edged Sword for Health? (2018, background): “NF-κB is a transcription factor that regulates the expression of a variety of genes involved in inflammation and immunity, such as proinflammatory cytokines and enzymes, adhesion molecules, growth factors, acute-phase proteins, and immune receptors (48, 65).”