A model for gene therapy of human hereditary lymphedema

By M. Karkkainen, A. Saaristo, L. Jussila, Kaisa A. Karila, E. Lawrence, Katri Pajusola, H. Bueler, A. Eichmann, R. Kauppinen, M. Kettunen and 4 more. Proceedings of the National Academy of Sciences of the United States of America, 2001

628 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/6f2fb081c08d2e6f0f5885240aafa9e60b6a34b3

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Citations in the corpus

Vascular endothelial growth factor (VEGF) signaling in tumor progression. (2007, background): “EGF-145, VEGF-165, PlGF-152 and VEGF-C bind to europilin-2 [150,151].”
The lymphatic vasculature in disease (2011, background): “In a mouse model of Milroy's disease, the resulting defective lymphangiogenesis can be rescued by therapeutic delivery of excess VEGF-C, which generates functional lymphatic capillarie”
Signal transduction by vascular endothelial growth factor receptors. (2012, background): “Also, the Chy-mouse mutant whose phenotype is characterized by accumulation of chylous ascites, carries a point mutation in the VEGFR3 tyrosine kinase domain, which renders the kinase enzymatically inactive (Karkkainen et al. 2001).”
Molecular mechanisms of lymphangiogenesis in health and disease. (2002, background): “Future studies will need to address the differences in the molecular “lymphangiogenic switch” between lymphatic vessels in the skin versus the visceral organs or the larger connecting lymphatic vessels, as those vessels are differently regulated by VEGFR-3 signals (Karkkainen et al., 2001).”
Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis (2004, background): “The fact that reduction of Vegfr3 signaling leads to lymphatic hypoplasi”
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins (2004, background): “In addition, VEGF-C also binds to neuropilin-2 (NRP-2”
Abnormal lymphatic vessel development in neuropilin 2 mutant mice. (2002, background): “NRP2 has also been shown to bind several VEGF family members, including VEGF165, VEGF145, PlGF and VEGFC (Karkkainen et al., 2001) (reviewed by Neufeld et al., 2002).”
Lymphangiogenesis in development and human disease (2005, background): “VEGF-C and VEGF-D also bind to neuropilin-2 (Nrp2), a semaphorin receptor in the nervous system that is also expressed in lymphatic capillarie”