Lymphangiogenesis in development and human disease

By K. Alitalo, T. Tammela, T. Petrova. Nature, 2005

1,296 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/122aa4ce8878ecc638ec0bdad53e7116626be84c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Rakesh K. Jain
2. N. Ferrara
3. Dai Fukumura
4. H. Wiig
5. K. Alitalo
6. M. Swartz
7. A. Adamis
8. R. Apte

In Oncology

1. Rakesh K. Jain
2. H. Wiig
3. N. Ferrara
4. M. Swartz
5. Dai Fukumura
6. Daniel Chen
7. R. Apte
8. K. Alitalo

In Physiology

1. N. Ferrara
2. T. Tammela
3. K. Alitalo
4. Rakesh K. Jain

Citations in the corpus

• Lymphangiogenesis: Molecular mechanisms and future promise. (2010, background): “Lymphangiogenesis at sites of inflammatory insults is induced by macrophages and granulocytes, which produce ample amounts of VEGF-C and VEGF-D (Alitalo et al., 2005; Baluk et al., 2005).”
• Ten years of anti-vascular endothelial growth factor therapy (2016, background): “A highly homologous RTK, VEGFR3 (also known as FLT4) 39 was also described and later shown to bind VEGFC and VEGFD 9,27,28 (which promote both angiogenesis and the development of lymphatic vessels).”
• Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize (2007, background): “D can induce both angiogenesis and lymphangiogenesis and are associated with lymphatic metastasis in a variety of tumors [Alitalo et al., 2005].”
• VEGF in Signaling and Disease: Beyond Discovery and Development (2019, background): “VEGF-C and VEGF-D are primarily implicated in regulation of lymphangiogenesis (Alitalo et al., 2005).”
• Microvascular fluid exchange and the revised Starling principle. (2010, background): “Advances in understanding the molecular and genetic control of lymphangiogenesis have underpinned insights into the defects that underlie some hereditary lymphoedemas.(97,98) 10.”
• Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “Since our focus is lymph formation and transport, we will not cover the molecular regulation of lymphangiogenesis and lymphatic function but rather refer to excellent recent reviews addressing these topics (11, 12, 222, 305, 459), along with a review of how the interstitial microenvironment can infl”
• Targeting the tumour vasculature: insights from physiological angiogenesis (2010, background): “VEGFC and VEGFD primarily interact with VEGFR3, and stimulate lymphangiogenesi”
• Cancer metastasis: building a framework. (2006, neutral): “enous circulation (Alitalo et al., 2005).”
• Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration (2010, positive): “As the VEGF family plays a critical role in the regeneration of the BM SECs 6 , we hypothesized that VEGF-receptors 20 - 22 , including VEGFR2 or VEGFR3 also modulate LSEC function.”