Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis

By T. Petrova, Terhi Karpanen, Camilla Norrmén, R. Mellor, T. Tamakoshi, D. Finegold, R. Ferrell, D. Kerjaschki, P. Mortimer, Seppo Ylä-Herttuala and 2 more. Nature Medicine, 2004

594 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/b45af3db11e4d84c96151425759367535d677175

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In Molecular Biology

1. K. Alitalo
2. A. Armulik
3. T. Tammela
4. G. Genové
5. Shu Chien
6. C. Betsholtz
7. J. Chiu
8. Berislav Zlokovic

In Oncology

1. K. Alitalo
2. T. Tammela
3. Rakesh K. Jain
4. N. Ferrara
5. M. Shibuya
6. M. Swartz
7. H. Wiig
8. C. Iadecola

In Physiology

1. K. Alitalo
2. T. Tammela
3. C. Betsholtz
4. N. Ferrara

Citations in the corpus

• Lymphangiogenesis in development and human disease (2005, background): “Foxc2 is highly expressed in the developing lymphatic vessels as well as in lymphatic valves in adult”
• Lymphangiogenesis: Molecular mechanisms and future promise. (2010, background): “Although the early development of lymphatic vessels proceeds normally in the absence of Foxc2, the collecting lymphatic vessels lack valves, and the lymphatic capillaries acquire an ectopic coverage by basement membrane components and smooth muscle cells (Petrova et al., 2004).”
• Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “In certain developmental abnormalities, or pathological situations, lymphatic capillaries may attract ectopic pericytes (Petrova et al., 2004).”
• Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives (2011, background): “(376) have demonstrated that mutations in the Foxc2 gene, which is located on chromosome 16 (421) and is expressed in both ECs and SMCs of developing blood vessels (313) and on the venous and lymphatic valvular leaflets (457, 621), are strongly associated with primary valve failure in veins of the l”