Neutrophil Extracellular Traps Kill Bacteria

By V. Brinkmann, U. Reichard, C. Goosmann, B. Fauler, Yvonne Uhlemann, D. Weiss, Y. Weinrauch, Arturo Zychlinsky. Science, 2004

9,686 citations recorded by the source corpus.

Subfields: Immunology, Microbiology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/6ea6aacb2ea239b989522bf66fbe5a450667aa1b

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In Immunology

In Microbiology

In Pulmonary and Respiratory Medicine

Citations in the corpus

Neutrophil serine proteases: specific regulators of inflammation (2006, background): “In addition to the intracellular activities of the neutrophil serine proteases, Brinkmann et al”
Surface Proteins of Staphylococcus aureus (2019, background): “Neutrophils also contribute to the host defenses by releasing DNA, which forms neutrophil extracellular traps (89).”
B–helper neutrophils stimulate immunoglobulin diversification and production in the marginal zone of the spleen (2011, background): “These structures arise after cell death and consist of decondensed chromatin embedded with granular and cytoplasmic proteins that trap and kill microbe”
Diverse stimuli engage different neutrophil extracellular trap pathways (2017, background): “Another form of defence utilised by the neutrophil is the release of decondensed chromatin decorated with antimicrobial peptides that can capture the pathogen in a process termed neutrophil extracellular trap (NET) formation (Brinkmann et al., 2004).”
The Multifaceted Functions of Neutrophils (2013, background): “In 2004, Zychlinsky and colleagues (115) described a process (since coined NETosis) by which neutrophils extrude a meshwork of chromatin fibers decorated with granulederived antimicrobial peptides and enzymes such as neutrophil elastase and MPO.”
Metabolic Regulation of Immune Responses (2014, background): “In addition, NADPH oxidase was recently shown to be required for the process of ‘netosis’, whereby neutrophils release their mitochondrial DNA in net-like structures to facilitate bacterial trapping (23, 24).”
Neutrophils and immunity: challenges and opportunities (2006, background): “Even the nuclei of neutrophils contribute to host defence by extruding their chromatin, which forms extracellular nets decorated with proteases from the azurophil granule”
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. (2012, background): “Activated neutrophils have recently been described to undergo NETosis, a unique type of cell death that is distinct from apoptosis and necrosis, in which neutrophil nuclear DNA is released in long chromatin filaments that form web-like structures decorated with granular proteins, called NETs (11).”
Platelets at the interface of thrombosis, inflammation, and cancer. (2015, background): “The resultant web-like networks of chromatin, histones, and degradative enzymes known as neutrophil extracellular traps (NETs) capture circulating microbes and thus limit their ability to colonize alternate sites.(35,36) Both in vitro and in vivo studies have illustrated that activated platelets adh”
Beneficial suicide: why neutrophils die to make NETs (2007, background): “Neutrophil extracellular traps (NETs) are extracellular structures that are composed of chromatin, with specific proteins from the neutrophilic granules attache”