Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury.
By A. Caudrillier, K. Kessenbrock, B. Gilliss, J. Nguyen, M. Marques, M. Monestier, P. Toy, Zena Werb, M. Looney. Journal of Clinical Investigation, 2012
972 citations recorded by the source corpus.
Subfields: Genetics, Immunology, Physiology
View Paper: https://www.semanticscholar.org/paper/87a09b44c6799dc0fbdcc059c3fce2d046d95908
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In Genetics
In Immunology
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In Physiology
Citations in the corpus
- Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. (2014, background): “Platelets are implicated in the activation of neutrophils and participate in the formation of neutrophil extracellular traps (NETs),44 a recognized feature found in RA and transfusion adverse reactions like TRALI.45,46 Interestingly, freeMitos are also NET inducers, a phenomenon that is amplified in”
- Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice (2018, background): “Given that our antibody preserves normal integrin b1 signaling, it may be a potent strategy to prevent cancer recurrence and more broadly serve as a treatment for other NETassociated pathologies, such as transfusion-related acute lung injury (41).”
- Platelets in Inflammation and Atherogenesis (2015, background): “Specifically, plateletinduced NET formation may play a role in viral infections (77) or transfusion-related lung injury (78).”
- Neutrophil extracellular traps: Is immunity the second function of chromatin? (2012, background): “There, activated platelets stimulate neutrophils to form NETs (Clark et al., 2007; Caudrillier et al., 2012), which serve as a pro thrombotic scaffold and bind and activate FXII (von Brühl et al.”
- Platelets at the interface of thrombosis, inflammation, and cancer. (2015, background): “The interaction between platelets and Kupffer cells in the liver appears to contribute to clearance of both bacterial cells and platelets during infection.24,28,29 Interestingly, TLRs aren’t the only platelet receptors capable of interacting with microbes; surface membrane glycoproteins, such as int”
- Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “Although NET generation has been described initially as an antimicrobial mechanism, recent data suggest that NETs could play a more important role in autoimmune and autoinflammatory pathologies, such as vasculitis [71], lung injury [72,73], atherosclerosis [74], rheumatoid arthritis [75,76], thrombo”