Neutrophil serine proteases: specific regulators of inflammation

By Christine T. N. Pham. Nature reviews. Immunology, 2006

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Tumor-associated neutrophils: new targets for cancer therapy. (2011, background): “Activated neutrophils also release proteinases into the extracellular environment, leading to damage of surrounding host tissue (4).”
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “Neutrophils are the most abundant blood leukocyte type and rapidly react to inflammatory responses (133).”
Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “Amongst the broad armamentarium that neutrophils carry in their granules, neutrophil serine proteases directly kill microbes and inactivate bacterial toxins [32,33].”
The impact of the extracellular matrix on inflammation (2010, background): “Current data suggest that the role of proteases in inflammation is strictly controlled and that, rather than being important in the early extravasation steps, they instead act to fine-tune the nature of the immune response or to remodel the interstitial matrix during chronic inflammatio”
Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases (2010, background): “NSPs are currently viewed as multifunctional enzymes involved in pathogenic agent killing and in inflammatory process regulation (Pham, 2006).”