Beneficial suicide: why neutrophils die to make NETs

By V. Brinkmann, Arturo Zychlinsky. Nature Reviews Microbiology, 2007

960 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b44c85f86d4845da447bb8455c97d9d4bf6904da

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps (2010, background): “The role of NETs in innate immunity has kindled much attention due to its involvement in human health and diseases and its therapeutic implications (Brinkmann and Zychlinsky, 2007; Nizet, 2007; Wartha and HenriquesNormark, 2008; von Köckritz-Blickwede and Nizet, 2009).”
Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview (2017, background): “Suicidal NETosis is dependent on ROS for histone citrullination by PAD4, which allows chromatin decondensation (16, 17, 19), finally releasing the DNA as extracellular traps (ETs) (Figure 1) (20, 21).”
Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus (2011, background): “of infections and are believed to play an important role in the fight against extracellular bacteria through their ability to entrap and kill these microbes (25, 27).”
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality (2011, positive): “histones and their cleavage products, such as buforin, have potent antimicrobial effects, and their microbicidal effects are enforced when they are concentrated in NET structures.(14,15)”
Neutrophils, from marrow to microbes. (2010, background): “Large strands of decondensed DNA are extruded from the cell, carrying along with them proteins from cytosol, from granules (which also disintegrated at the same time as the nuclei dissolve), and from chromatin (histones) (Brinkmann and Zychlinsky, 2007; Brinkmann et al., 2004; Fuchs et al., 2007).”
Thrombosis: tangled up in NETs. (2014, background): “Finally, the chromatin network is released into the extracellular milieu.(1,7,11) What happens to the plasma membrane, cytoskeleton, and other organelles during NETosis is not known.”
Reactive oxygen species and mitochondria: A nexus of cellular homeostasis (2015, background): “compounds released from neutrophils into a constrained area [69,70].”
Reactive Oxygen Species and Neutrophil Function. (2016, background): “Although much of the evidence is still inferential, they are proposed to have a positive function in host defense by trapping and aiding in the removal of bacteria (96).”
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. (2012, background): “These NETs have been shown to exhibit antimicrobial functions by trapping and killing extracellular pathogens in blood and tissues during infection (12).”
Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps (2009, background): “Moreover, NETs were released in association with cell membrane breaks as a consequence of neutrophil death.(3,10) In contrast, the generation of the mixed extracellular DNA/granule protein structures by eosinophils did not require their cell death.”
Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis (2010, background): “NETs are formed through a unique cell death program (13) and are composed of chromatin and neutrophil proteins (14).”