Lipotoxic diseases.

By R. Unger. Annual Review of Medicine, 2002

701 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/6e4ca0727d789ed32fa513c1f0f99b5346bf2f79

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In Endocrine and Autonomic Systems

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Citations in the corpus

Oxygen, oxidative stress, hypoxia, and heart failure. (2005, background): “Lipotoxicity and ROS Myocardial lipotoxicity refers to the accumulation of intramyocardial lipids concomitant with contractile dysfunction, often associated with myocyte death (87, 88).”
Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. (2003, background): “Together, these studies in rodents suggest that adiponectin may play an important role in preventing the development of lipotoxicity in insulin-sensitive tissues that commonly occurs in the metabolic syndrome (40).”
Obesity, metabolic syndrome, and cardiovascular disease. (2004, background): “Regardless, this hormone has been reported to have a beneficial effect on the liver to protect against fatty liver (23).”
Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity (2010, positive): “This dysregulation of fatty acid and glucose metabolism induced by elevated lipids in β-cells, liver, and skeletal muscle has been termed lipotoxicity (3).”
Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. (2008, background): “In rodent models of type 2 diabetes, increases in islet ceramide and triglyceride precede -cell dysfunction and destruction (230, 242).”
Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. (2006, background): “Lipolytic activities in adipose tissue modulate the concentration of FFA in plasma, which, when chronically elevated, exert a lipotoxic effect on many nonadipose tissues (Schaffer, 2003; Unger, 2002) and contribute to the development of insulin resistance (Boden and Shulman, 2002).”
Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease. (2010, background): “This excessive accumulation of intramyocellular fatty acids and their metabolites has been referred to as lipotoxicity and is a main contributor to the pathophysiology of insulin resistance and dysfunctioning of heart and skeletal muscle (194, 451).”
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500294-JLR200 (2005, background): “In WAT, “free” lipid droplets released from necrotic adipocytes must be sequestered and removed from the interstitium, since they are insoluble and provide an unprotected source of cholesterol and cytotoxic fatty acids that could damage WAT cells (44, 54, 55).”
Fat Tissue, Aging, and Cellular Senescence (2010, background): “Fat tissue and aging, T. Tchkonia et al. ª 2010 The Authors Aging Cell ª 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 673 (Unger, 2002; Xu et al., 2002; Listenberger et al., 2003; DeFronzo, 2004; Tchkonia et al., 2006a; Kim et al., 2007).”
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “Unger (62) has coined the term lipotoxicity to describe the deleterious effect of chronic FFA elevation on insulin secretion by the pancreatic -cells.”