Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome.
By A. Lass, R. Zimmermann, G. Haemmerle, M. Riederer, Gabriele Schoiswohl, M. Schweiger, P. Kienesberger, J. Strauss, G. Gorkiewicz, R. Zechner. Cell Metabolism, 2006
897 citations recorded by the source corpus.
Subfields: Biochemistry, Physiology, Surgery
View Paper: https://www.semanticscholar.org/paper/716a5aa58491127b836452972ad733374a7d18d2
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Citations in the corpus
- Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores (2011, background): “Replacement of Ser47 of the murine protein or Asp166 of the human protein with an alanine in both cases led to catalytically inactive proteins [8,46].”
- PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores (2009, background): “Perhaps most intriguingly, mouse CGI-58 with an E260K mutation, the same mutation reported by Zechner’s group to block the interaction of human CGI-58 with perilipin [61], also blocked its interaction with OXPAT.”
- Energy Metabolism in the Liver (2014, neutral): “CGI-58, an endogenous activator of ATGL, binds to perilip-ins under basal conditions; catecholamine hormones stimulate phosphorylation of perilipins which releases CGI-58, allowing it to activate ATGL and stimulate lipolysis (67, 129).”
- Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis (2011, background): “The phosphorylation of perilipin A releases CGI-58, allowing it to interact with Pnpla2 to enhance the lipolysis of stored triglyceride”
- Transcriptional control of adipose lipid handling by IRF4 (2011, neutral): “Several other factors have recently been discovered to acutely regulate lipolysis, such as CGI-58 (Lass et al., 2006), AdPLA (Jaworski et al., 2009), and G0S2 (Yang et al., 2010); however, we have not been able to demonstrate significant effects of IRF4 on the expression of any of these mediators…”
- Lipids of mitochondria. (2013, background): “The cardiolipin-specific deacylase 1 (Cld1) is exclusively localized to mitochondria and shows distant homology to the mammalian protein CGI-58, an activator of the mammalian triacylglycerol lipase ATGL [132].”
- Regulation of lipolysis in adipocytes. (2007, positive): “(66) demonstrated that CGI-58 stimulates in vitro lipolysis and is an activator of ATGL, but not HSL.”
- Triglyceride metabolism in the liver (2017, neutral): “Liver-specific ablation of CGI-58 results in NAFLD phenotypes in mice that include hepatic steatosis and fibrosis (109).”