The snoRNA HBII-52 Regulates Alternative Splicing of the Serotonin Receptor 2C

By Shivendra Kishore, Stefan Stamm. Science, 2006

716 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6e4b061c48fbada149434f02e98993b4f054a35c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. John S. Mattick
2. Marcel E. Dinger
3. Tim R. Mercer
4. Manel Esteller
5. Ryan J. Taft
6. Ken C. Pang
7. A. Krek
8. Nikolaus Rajewsky

In Molecular Biology

1. John S. Mattick
2. Marcel E. Dinger
3. Tim R. Mercer
4. Ryan J. Taft
5. R. Sperling
6. D. Rio
7. Yeon J. Lee
8. Manel Esteller

Citations in the corpus

• The relationship between non-protein-coding DNA and eukaryotic complexity. (2007, background): “We suggest that the lack of correlation in the latter is explained by the evolution of an increasingly sophisticated architecture to control gene expression and gene product diversity during multicellular ontogeny, involving both the expansion of cis-acting regulatory elements acting at multiple lev”
• A human snoRNA with microRNA-like functions. (2008, background): “Moreover, snoRNAs have also been implicated in alternative splicing events (Kishore and Stamm, 2006).”
• Non-coding RNA. (2006, background): “The snoRNA HBII-52 which regulates the splicing of the serotonin receptor 5-HT(2C )R gene is not expressed in Prader–Willi syndrome patients which have different 5-HT(2C)R mRNA isoforms from normal, suggesting that this defect contributes to the Prader–Willi syndrome (64,102).”
• Non‐coding RNAs: regulators of disease (2010, background): “Interestingly, HBII-52 forms an antisense duplex with the serotonin receptor 2C (5HT2C ) mRNA and negatively regulates its post-transcriptional editing [146,147], strongly implicating it in PWS-associated and autistic neurological defects [148].”
• The nuts and bolts of the endogenous spliceosome (2017, background): “A noncanonical function in alternative splicing was demonstrated for the ‘orphan’ neuron-specific SNORD115, which promoted the inclusion of an alternative exon of the serotonin receptor 2C, generating an active receptor.(104,105) Another case is SNORD88C, which has an antisense sequence complementar”
• Epigenetics in alternative pre-mRNA splicing (2011, neutral): “An intriguing extension of these considerations is the possibility that noncoding RNAs might play a role in alternative splicing regulation (Kishore and Stamm, 2006; Khanna and Stamm, 2010). ncRNAs are now known to be involved in heterochromatin structure, and it is possible that some ncRNAs are…”
• GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer (2009, background): “For example, snoRNA HBII-52 regulates alternative splicing of serotonin receptor 2C (Kishore and Stamm, 2006), and other snoRNAs help to control RNA editing (Vitali and Cavaille, 2005).”
• Mechanisms and Regulation of Alternative Pre-mRNA Splicing (2015, background): “RNA–RNA base pairing can also occur in trans, exemplified by the small nucleolar RNA (snoRNA) HBII–5252B RNA, which regulates the serotonin receptor 2C transcript (17, 18).”
• Non-coding RNAs in human disease (2011, background): “These disorders are caused by several genetic and epigenetic mechanisms involving the 15q11–q13 imprinted locus, which contains a cluster of tandemly arranged snoRNA”
• Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches (2009, background): “Gene_RVDocSum"> HTR2C pre-mRNA by binding to a silencing element in exon Vb to promote its inclusio”