Epigenetics in alternative pre-mRNA splicing

By R. Luco, Maria Alló, Ignacio E Schor, A. Kornblihtt, Tom Misteli. Cell, 2011

807 citations recorded by the source corpus.

Alternative splicing plays critical roles in differentiation, development and disease and is a major source for protein diversity in higher eukaryotes. Traditionally, analysis of alternative splicing regulation has focused on RNA sequence elements and their associated factors, but recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation. These insights suggest that epigenetic regulation not only determines what parts of the genome are expressed, but also how they are spliced.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e1d8be94e4fdc88091a55c5aa0fbb6f913878758

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In Molecular Biology

Citations in the corpus

Alternative Splicing at the Intersection of Biological Timing, Development, and Stress Responses[OPEN] (2013, background): “…and AS emerges, where transcription can affect expression levels of SFs and AS of genes dependent on the rate of transcription of RNA polymerase II (Luco et al., 2011); AS can influence the level of transcription factor expression via AS/NMD and the domain composition of transcription factors.”
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing (2011, neutral): “Accordingly, several recent studies suggest that exonic histone modification may affect variable inclusion of alternative exon”
Complexity of the Alternative Splicing Landscape in Plants[C][W][OPEN] (2013, background): “The accumulating data on AS in different plants across the phylogenetic spectrum will allow the development of computational tools to identify conserved, lineage-specific AS and predict regulatory elements (enhancers and suppressors) that determine the outcomes of splicing.”
Mechanisms and Regulation of Alternative Pre-mRNA Splicing (2015, background): “Several examples of links between chromatin and splicing have been discovered (20, 26, 183, 184).”
Mechanisms and consequences of alternative polyadenylation (2011, neutral): “Chromatin and Epigenetic-Mediated Regulation of APA An important recent discovery is that chromatin structure and epigenetic marks can act as regulators of alternative splicing (Fox-Walsh and Fu, 2010; Luco et al., 2010, 2011).”
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) (2011, background): “This suggests that generation of the splicing variants is probably due to a mutation or epigenetic change that affects BRAF splicing and not to a loss of global splicing fidelit”
The RNA polymerase II CTD coordinates transcription and RNA processing. (2012, background): “…surprising that splicing and transcription are coupled, as this provides a mechanism to enhance the fidelity and efficiency of splicing as well as its regulation, and while other factors function in this coupling (e.g., Luco et al. 2011), it is also not surprising that the CTD plays a central role.”
Gene Body Methylation can alter Gene Expression and is a Therapeutic Target in Cancer (2014, background): “Therefore, nucleosome destabilization in the exon-intron junctions may alter mRNA levels (Andersson et al., 2009; Luco et al., 2011; Tilgner et al., 2009).”
diffReps: Detecting Differential Chromatin Modification Sites from ChIP-seq Data with Biological Replicates (2013, background): “For example, many histone marks have been implicated in the regulation of pre-mRNA alternative splicing [7].”