Neurotrophin signal transduction in the nervous system.

By D. Kaplan, F. Miller. Current Opinion in Neurobiology, 2000

2,040 citations recorded by the source corpus.

Subfields: Cancer Research, Cellular and Molecular Neuroscience, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/6dad83366ac9c6c2d61cd6f43f0241f07bad4191

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Citations in the corpus

Activation of p75NTR by proBDNF facilitates hippocampal long-term depression (2005, background): “Mature BDNF interacts preferentially with TrkB to activate its intrinsic tyrosine kinase activity, which in turn triggers multiple intracellular signaling pathway”
Brain-Derived Neurotrophic Factor Induces Long-Term Potentiation in Intact Adult Hippocampus: Requirement for ERK Activation Coupled to CREB and Upregulation of Arc Synthesis (2002, background): “as neuronal differentiation and growth (Kaplan and Miller, 2000).”
SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease. (2010, background): “These receptors mediate almost all of their survival-promoting activities, with NGF preferentially activating TrkA and BDNF, NT-4/5 activating TrkB, and NT-3 activating TrkC sites.(44) In addition, several other growth factors, including basic fibroblast growth factor (bFGF), insulin-like growth fac”
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer’s disease (2009, background): “, where it is implicated in plasticity mechanisms hypothesized to underlie learnin”
Brain-derived neurotrophic factor and its clinical implications (2015, background): “Trk receptor-mediated signaling is controlled through expression of intermediates in these signaling pathways that regulate localization of different signaling constituents [21–23].”
Neurotrophin secretion: current facts and future prospects. (2003, background): “The present knowledge about these two types of receptors and the intracellular signaling mechanisms that follow their activation has been extensively reviewed elsewhere (see, e.g.Kaplan and Miller, 2000; Patapoutian and Reichardt, 2001; Roux and Barker, 2002) and will not be addressed here.”
The gene PC3TIS21/BTG2, prototype member of the PC3/BTG/TOB family: Regulator in control of cell growth, differentiation, and DNA repair? (2001, background): “The ®nal target of both pathways might be p53 that would induce death genes as BAX that trigger apoptosis (see for review Kaplan and Miller, 2000).”
Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects (2003, background): “Tyrosine 515 (analogous to Y490 in trkA) is the docking site of the shc adaptor protein, which leads to the activation of the extracellular signal-regulated kinase/mitogenactivated protein kinase pathway (Kaplan and Miller, 2000; Huang and Reichardt, 2001).”
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone (2010, background): “BDNF | neuroprotection | small molecule | binding BDNF, a member of the neurotrophin family, exerts its bio-logical functions through two transmembrane receptors: the p75 neurotrophin receptor and the tyrosine kinase receptor B (TrkB) (NGF binds to TrkA, BDNF and NT-4/5 bind to TrkB, and NT-3 prefer”
Neurotrophins and their receptors: A convergence point for many signalling pathways (2003, background): “In the case of TrkB and TRPC3, TrkB-mediated PLC-γactivity leads to the opening of TRPC3 through inositol-1,4,5-triphosphate (Ins(1,4,5)P3) generation and store-operated calcium release.”
TrkB signalling pathways in LTP and learning (2009, background): “Three main intracellular signalling cascades are activated by the TrkB receptor: the Ras–mitogen-activated protein kinase (MAPK) pathway, the phosphatidylinositol 3-kinase (PI3K)–Akt pathway and the PLCγ–Ca 2+ pathwa”
Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. (2000, background): “Phosphorylated Shc leads to the activation of the Ras/ Raf/MEK/MAPK pathway (for review, see Kaplan and Miller 2000).”
Potential therapeutic uses of BDNF in neurological and psychiatric disorders (2011, background): “As with other neurodegenerative disease models, the mechanisms underlying the neuroprotective and functional effects of BDNF include activation of signalling in neuronal pro-survival pathways, including phospho-inositide 3-kinase and AKT, and enhancement of cell function via activation of the mitoge”
BDNF and activity-dependent synaptic modulation. (2003, background): “Activated receptors in general are capable of triggering a number of signal transduction cascades including the MAPK pathway, the phosphatidylinositol 3-kinase (PI3K) pathway, and the phospholipase C- (PLC- ) pathway (Kaplan and Miller 2000; Patapoutian and Reichardt 2001).”