A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

By Sung-Wuk Jang, Xia Liu, Manuel Yepes, K. Shepherd, G. Miller, Yang Liu, W. David Wilson, Ge Xiao, B. Blanchi, Y. Sun and 4 more. Proceedings of the National Academy of Sciences of the United States of America, 2010

683 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology, Plant Science

View Paper: https://www.semanticscholar.org/paper/a2d903b6927a55cdb081d03996b24cbafac5924b

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In Molecular Biology

1. Anita E. Autry
2. L. Monteggia

In Pharmacology

1. Anita E. Autry
2. L. Monteggia

Citations in the corpus

• GDNF, NGF and BDNF as therapeutic options for neurodegeneration. (2013, background): “It was shown to be protective in mice models of toxicity by kainic acid, stroke and PD (Jang et al., 2010).”
• Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders (2012, background): “BDNF “mimetic” peptides have been developed in the last several years (Yang et al., 2005; Fletcher et al., 2008; Jang et al., 2010).”
• Psychedelics Promote Structural and Functional Neural Plasticity (2018, background): “As a positive control, we treated cells with 7,8-dihydroxyflavone (DHF), a psychoplastogen structurally dissimilar to classical psychedelics (Jang et al., 2010), and found that it also increased dendritic arbor complexity (Figure S2).”