Brain-Derived Neurotrophic Factor Induces Long-Term Potentiation in Intact Adult Hippocampus: Requirement for ERK Activation Coupled to CREB and Upregulation of Arc Synthesis

By S. Ying, M. Futter, K. Rosenblum, M. Webber, S. Hunt, T. Bliss, C. Bramham. Journal of Neuroscience, 2002

807 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c1daa68b2a57d89fd0d2e2e04f519b16f66ccdfe

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. H. van Praag
2. Fred H. Gage
3. Mariana Alonso
4. W. Tyler
5. P. Lacor
6. P. Velasco
7. C. Duarte
8. Akira Yoshii

In Developmental Neuroscience

1. H. van Praag
2. Fred H. Gage
3. Mariana Alonso
4. C. Duarte
5. C. Bramham
6. Graciano Leal
7. Diogo Comprido
8. Hongjun Song

In Molecular Biology

1. C. Duarte
2. Fred H. Gage
3. Akira Yoshii
4. Volkmar Lessmann
5. C. Bramham
6. Graciano Leal
7. K. Gottmann
8. Diogo Comprido

Citations in the corpus

• BDNF — a key transducer of antidepressant effects (2015, neutral): “BDNF infusion into the hippocampus may also induce LTP in vivo (Ying et al., 2002), confirming the physiological relevance of this finding.”
• Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease (2007, background): “Supporting this possibility, ADDLs ectopically induce Arc (Lacor et al., 2004), a spine cytoskeletal protein that influences glutamate receptor trafficking (Mokin et al., 2006).”
• Post-synaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity and Disease (2010, positive): “TrkB activation by cAMP induces nuclear translocation of the activated MAPK to the nucleus and CREB protein phosphorylation (Pizzorusso et al., 2000; Ying et al., 2002).”
• Neurotrophin secretion: current facts and future prospects. (2003, background): “, 2002), this BDNF-induced LTP in the dentate gyrus in vivo also involves CREB signaling, which subsequently enhances the expression of the dendritic activity-regulated cytoskeleton-associated protein (Arc), but in addition also relies on intact MAPK signaling ( Ying et al., 2002).”
• Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. (2006, neutral): “1-inducing stimuli trigger enduring changes in synaptic plasticity and behavior (Bock et al., 2005; Gusev et al., 2005; Guthrie et al., 2000; Kelly and Deadwyler, 2002; Montag-Sallaz et al., 1999; Ying et al., 2002).”
• BDNF-induced local protein synthesis and synaptic plasticity. (2014, positive): “Furthermore, BDNF induces the expression of genes coding for regulators of synaptic activity, such as Arc (Ying et al., 2002; Zheng et al., 2009) and several synaptic vesicle proteins, including vesicular glutamate transporters (Melo et al., 2013; Tartaglia et al., 2001).”