From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning.

By W. Tyler, Mariana Alonso, C. Bramham, Lucas Pozzo-Miller. Learning & memory (Cold Spring Harbor, N.Y.), 2002

750 citations recorded by the source corpus.

One of the most rigorously investigated problems in modern neuroscience is to decipher the mechanisms by which experience-induced changes in the central nervous system are translated into behavioral acquisition, consolidation, retention, and subsequent recall of information. Brain-derived neurotrophic factor (BDNF) has recently emerged as one of the most potent molecular mediators of not only central synaptic plasticity, but also behavioral interactions between an organism and its environment. Recent experimental evidence indicates that BDNF modulates synaptic transmission and plasticity by acting across different spatial and temporal domains. BDNF signaling evokes both short- and long-term periods of enhanced synaptic physiology in both pre- and postsynaptic compartments of central synapses. Specifically, BDNF/TrkB signaling converges on the MAP kinase pathway to enhance excitatory synaptic transmission in vivo, as well as hippocampal-dependent learning in behaving animals. Emerging concepts of the intracellular signaling cascades involved in synaptic plasticity induced through environmental interactions resulting in behavioral learning further support the contention that BDNF/TrkB signaling plays a fundamental role in mediating enduring changes in central synaptic structure and function. Here we review recent literature showing the involvement of BDNF/TrkB signaling in hippocampal-dependent learning paradigms, as well as in the types of cellular plasticity proposed to underlie learning and memory.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/6c181426292894e0b96bca249c4e8df322b279a8

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

B. K. Pedersen

Citations in the corpus

Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour. (2015, background): “The neuroprotective role of BDNF in the brain, and the association between altered levels in the hippocampus and learning and memory performance is well established (Mizuno et al., 2000; Tyler et al., 2002; Baj et al., 2013).”
Brain-Derived Neurotrophic Factor val66met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance (2003, background): “…only regulates cell survival, proliferation, and synaptic growth in the developing CNS but also is a critical element in modulating synaptic changes, such as hippocampal long-term potentiation (LTP), associated with learning and adaptive behaviors in adult animals (Poo, 2001; Tyler et al., 2002).”
Mouse and rat BDNF gene structure and expression revisited (2006, background): “BDNF supports the survival and differentiation of specific populations of embryonic neurons in vivo, and growing evidence indicates that BDNF is also involved in several functions in adulthood, including neuronal homeostasis and brain plasticity-related processes such as memory, learning (Tyler et a”
Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, neutral): “(Tyler et al, 2002; Pang et al, 2004; Lu and Woo, 2006).”
Transcranial pulsed ultrasound stimulates intact brain circuits. (2010, background): “This particularly intriguing possibility is supported by our observations in mice that transcranial US can promote sharp-wave ripple oscillations (Figures 7C and S5) and stimulate the activity of endogenous BDNF (Figure 7D), an important regulator of brain plasticity and hippocampal-dependent memory”
Brain-derived neurotrophic factor (BDNF) and type 2 diabetes (2007, background): “In addition, BDNF plays a role in learning and memory (for review see [2]).”
Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus. (2007, positive): “BDNF has been extensively implicated in synaptic plasticity and memory processing, and it has been demonstrated to be essential for the development of the protein synthesis-dependent late phase of long-term potentiation (L-LTP) (Kang et al., 1997; Korte et al., 1995; Pang et al., 2004; Patterson et ”
The synapsins: key actors of synapse function and plasticity. (2010, background): “It is well established that BDNF/TrkB signalling can modulate pre-synaptic function and learning (Xu et al., 2000; Tyler et al., 2002; Zhang and Poo, 2002), and BDNF increased glutamate release from synaptosomes through an Erk-dependent phosphorylation of syn I (Jovanovic et al.”
The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk (2009, background): “BDNF is recognized as playing a key role in regulating survival, growth and maintenance of neurons (Mattson et al. 2004), and it plays a role in learning and memory (Tyler et al. 2002).”