Brain-derived neurotrophic factor (BDNF) and type 2 diabetes

By K. Krabbe, A. Nielsen, R. Krogh-Madsen, P. Plomgaard, P. Rasmussen, C. Erikstrup, C. Fischer, B. Lindegaard, A. M. Petersen, S. Taudorf and 4 more. Diabetologia, 2007

676 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/079c3e63ec33ffda578b9c97de9ce39e5c758e1f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. B. K. Pedersen
2. M. Otto
3. Kristin L. Szuhany
4. Undurti N. Das
5. Matteo Bugatti
6. Siresha Bathina

In Developmental Neuroscience

1. B. K. Pedersen

Citations in the corpus

• Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase (2009, background): “Recently, we demonstrated a strong association between low plasma BDNF and type 2 diabetes on the one hand and both obesity and insulin resistance on the other [37].”
• Brain foods: the effects of nutrients on brain function (2008, neutral): “Low levels of BDNF in the plasma are associated with impaired glucose metabolism and type II diabete”
• Muscles and their myokines (2011, background): “This last finding may explain the concomitant finding of low circulating levels of BDNF in individuals with type 2 diabetes, and the association between low plasma BDNF and the severity of insulin resistance (Krabbe et al., 2007).”
• Brain-derived neurotrophic factor and its clinical implications (2015, background): “BDNF not only regulated glucose and energy metabolism but also prevented exhaustion of the pancreas in diabetic mice by maintaining the histologic cellular organization of β cells and non-β cells in pancreatic islets and restoring the level of insulin-secreting granules in β cells [105] and thus ame”
• A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor (2014, result): “…of BDNF, given the ability to measure BDNF centrally; however, studies indicate that peripheral (serum and plasma) and central BDNF levels are correlated in mouse models (Angelucci et al., 2011; Karege et al., 2002), with some evidence for similar associations in humans (Krabbe et al., 2007).”
• The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk (2009, background): “Hippocampal samples from Alzheimer’s disease donors show decreased BDNF expression (Connor et al. 1997) and individuals with Alzheimer’s disease have low plasma levels of BDNF (Laske et al. 2005).”