Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus.

By P. Bekinschtein, M. Cammarota, L. Igaz, L. Bevilaqua, I. Izquierdo, J. Medina. Neuron, 2007

635 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/e2fcd99ed14cc6e64d36c0120a41818ee6c246e1

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Developmental Neuroscience

Citations in the corpus

Translational control of long-lasting synaptic plasticity and memory. (2009, positive): “However, recent evidence suggests that there is more than one wave of protein synthesis during the memory consolidation process (Bekinschtein et al., 2007; Bourtchouladze et al., 1998).”
Synaptic Consolidation: From Synapses to Behavioral Modeling (2015, background): “Our simulations provide an explicit link between cellular and behavioral consolidation mechanisms (Bekinschtein et al., 2007; Moncada and Viola, 2007; Wang et al., 2010) and make two specific predictions.”
TrkB signalling pathways in LTP and learning (2009, background): “It has been shown that blocking protein synthesis and BDNF expression in the rat hippocampus during a restricted time window around 12 hours after training on a one-trial associative learning task caused a deficit in the persistence of LTM storage but not in memory formatio”
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain (2019, background): “For example, BDNF could be a mediator of the plastic changes underlying both spatial and recognition memory processes (Kesslak et al., 1998; Mizuno et al., 2000; Cirulli et al., 2004; Bekinschtein et al., 2007; Heldt et al., 2007).”
Making memories last: the synaptic tagging and capture hypothesis (2010, background): “The effect of these two actions — PRP synthesis and cytoskeletal changes — support the necessary role of BDNF in L-LT”
BDNF is essential to promote persistence of long-term memory storage (2008, background): “4] 12 h after IA training, which causes a selective deficit in memory retention 7 days, but not 2 days, after training (12).”