The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk

By B. K. Pedersen. Journal of Physiology, 2009

626 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Position statement. Part one: Immune function and exercise. (2011, background): “Chronic inflammation promotes the development of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth (104), and subsequently the development of a number of diseases associated with physical inactivity (218) (Figure 5).”
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise (2012, background): “Discovery ofmyokines has emphasized the role of muscle as a source of hormones that communicate information and interact with other tissues, including fat, liver, and pancreas, to alter metabolism [7–9].”
Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases (2015, background): “Inflammation contributes to the pathogenesis of Alzheimer’s disease (Pedersen, 2009).”
Muscles and their myokines (2011, background): “We have recently suggested that type 2 diabetes, CVD, colon cancer, breast cancer, dementia and depression constitute a cluster of diseases, which defines a ‘diseasome of physical inactivity’ (Pedersen, 2009b) (Fig.1).”
Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “The role of myokines has previously been reviewed (7, 11-37), identifying more than 650 myokines (38).”