Mitochondria and neuronal survival.

By D. Nicholls, S. Budd. Physiological Reviews, 2000

1,278 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6bf6af6c3e8b678c6de6881d726b024dd982f381

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Citations in the corpus

Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis (2000, background): “Recognizing that this H + pump can operate bidirectionall”
Mitochondrial dynamics regulates migration and invasion of breast cancer cells (2012, background): “The proton ionophore m-chlorophenylhydrazone (CCCP) disperses this proton gradient, thereby uncoupling mitochondrial respiration from ATP synthesis (30).”
ROS and ROS-Mediated Cellular Signaling (2016, background): “In this review paper, we particularly focus on the pattern of the generation and homeostasis of intracellular ROS, the mechanisms and targets of ROS impacting on cell-signaling proteins (NF-𝜅B, MAPKs, Keap1-Nrf2-ARE, and PI3K-Akt), ion channels and transporters (Ca2+ and mPTP), and modifying…”
A hyperfused mitochondrial state achieved at G1–S regulates cyclin E buildup and entry into S phase (2009, background): “A predictable decrease in mitochondrial potential after membrane depolarization by the protonophore carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP) (14) is observed.”
Mitochondria and neuronal activity. (2007, background): “Indeed, mitochondrial ROS formation at its major sites, namely, complex III and complex I, was shown to be decreased or completely inhibited by depolarization of the mitochondrial membrane (158, 206, 216).”
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production (2000, background): “Other reports have described a relationship between mitochondrial uncoupling and production of ROS (ref”
Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species (2004, background): “Reactive oxygen species (ROS) are thought to contribute to neuronal cell death caused by ischemia, excitotoxicity, and various acute and chronic neurological disorders (Dykens, 1994; Fiskum et al., 1999; Murphy et al., 1999; Fiskum, 2000; Nicholls and Budd, 2000).”
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration (2012, neutral): “jpg"/> Mitochondria are essential for neuronal function and surviva”
Oxidative stress, mitochondrial damage and neurodegenerative diseases (2013, background): “and Na + -K + -adenosine triphosphate synthases at the plasma membrane and consequently the activity of Na + -coupled plasma membrane transporters [43] .”
Calcium, ATP, and ROS: a mitochondrial love-hate triangle. (2004, background): “Although the mechanism of DCD is still under debate, it is agreed that the speed of DCD is strongly dependent on the magnitude of [Ca2 ]m AJP-Cell Physiol • VOL 287 • OCTOBER 2004 • www.ajpcell.org by 10.220.32.247 on O ctober 4, 2017 http://ajpcell.physiology.org/ D ow nloaded from accumulation, su”
PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death (2009, background): “Thus, repetitive rises in cytosolic calcium result in mitochondrial calcium overload, leading to premature opening of the PTP, profound mitochondrial depolarization, and ultimately cell death (Crompton, 1999; Nicholls and Budd, 2000).”
Mitochondrial membrane potential probes and the proton gradient: a practical usage guide. (2011, background): “Szabadkai G, Duchen MR. Mitochondria: the hub of cellular Ca2+ signaling.”