Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
By Zu-Hang Sheng, Qian Cai. Nature Reviews Neuroscience, 2012
895 citations recorded by the source corpus.
Mitochondria have a number of essential roles in neuronal function. Their complex mobility patterns within neurons are characterized by frequent changes in direction. Mobile mitochondria can become stationary or pause in regions that have a high metabolic demand and can move again rapidly in response to physiological changes. Defects in mitochondrial transport are implicated in the pathogenesis of several major neurological disorders. Research into the mechanisms that regulate mitochondrial transport is thus an important emerging frontier.
Subfields: Clinical Biochemistry, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/0755b0940cfa66bb73b041959230c283c36f9560
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Citations in the corpus
- Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System (2018, background): “These lines of evidence highlight the direct association between mitochondrial CB1R and proper functioning of mitochondria, which has been suggested to participate in many pathological conditions [84,85].”
- Matrix as an Interstitial Transport System (2014, background): “The myosin family (primarily myosin V) regulates mitochondrial transport along actin filaments.(181,182,187)”
- Hallmarks of neurodegenerative diseases. (2023, neutral): “99,104,189,190 194 , 195 The consequences of mitochondrial damage or dysregulation to the cell can be broad (Figure 3).”
- A comprehensive review of amyotrophic lateral sclerosis (2015, background): “Increased mitochondrial transport may slow axonal degeneration by delivering healthy mitochondria to axons while removing the damaged one from distal synapses.[264,331] Mitochondria have been an attractive target for ALS therapy development and drugs, such as olexisome, are already in clinical trial”
- Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, neutral): “Mobile mitochondria can halt in regions with high metabolic demands (Sheng and Cai, 2012), thus aberrant axonal transport could influence effective function of mitochondria.”
- Quantitative neuroanatomy for connectomics in Drosophila (2015, background): “Nonetheless, axons need transport of cytosolic elements such as vesicles and mitochondria, which are delivered primarily via microtubules, as well as the anchoring of such elements onto the microtubule cytoskeleton (Sheng and Cai, 2012).”
- Synaptic energy use and supply. (2012, neutral): “This has been reviewed extensively by MacAskill et al. (2010) and Sheng and Cai (2012), who provide more detail on the following points.”