Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
By D. Arsenijevic, H. Onuma, C. Pecqueur, S. Raimbault, B. Manning, B. Miroux, Elodie Couplan, M. Alves-Guerra, M. Goubern, R. Surwit and 4 more. Nature Genetics, 2000
1,123 citations recorded by the source corpus.
Subfields: Parasitology, Physiology, Rehabilitation
View Paper: https://www.semanticscholar.org/paper/32036d78f8a3f25cfb09bf93a0e2a95771a8008d
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In Physiology
- B. Spiegelman
- Christoph Handschin
- Jiandie D. Lin
- Wenli Yang
- Marc Uldry
- J. St-Pierre
- F. Picard
- Navdeep S. Chandel
In Rehabilitation
Citations in the corpus
- Mitochondrial reactive oxygen species in cell death signaling. (2002, background): “[29] D.”
- Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. (2005, background): “Since metabolic rate, metabolic efficiency, and obesity are integrated properties of the whole animal, researchers have produced mice lacking UCP2 [10] and UCP3 [11,12].”
- Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells (2005, neutral): “regulation of reactive oxygen species, and macrophagemediated immunity [28,34,35].”
- Mitochondrial ROS signaling in organismal homeostasis. (2015, background): “, 2010), and UCP2-dependent mtROS regulation is connected to both adaptive and innate immune cell functions (Arsenijevic et al., 2000; Horvath et al., 2003; Krauss et al., 2002).”
- ROS Function in Redox Signaling and Oxidative Stress (2014, background): “For example, mice lacking uncoupling protein 2 (UCP2) have higher levels of mitochondrial ROS and increased immunity to bacterial pathogens [99], suggesting that a low elevated level of ROS in the immune systemmight enhance normal immune function.”
- Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. (2006, background): “Another line of defense that limits ROS production by mitochondria is the uncoupling proteins (Arsenijevic et al., 2000; Echtay et al., 2002).”
- Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature. (2003, background): “The observation that ground squirrels fed diets high in ␣-tocopherol, an important ROS scavenger , are less likely to enter torpor and less likely to survive torpor (89) also supports the idea that a minimum level of oxidative stress may actually be required for normal hibernation patterns.”