Mitochondria and neuronal activity.

By Oliver Kann, R. Kovács. American Journal of Physiology - Cell Physiology, 2007

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Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, background): “Thus, brain energetics contributes to neurotransmission associated with cognitive dysfunction (Kann and Kovacs, 2007).”
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014, background): “Accordingly, mitochondrial impairment has a great impact on neuronal function and survival (Nicholls & Budd, 2000; Kann & Kovács, 2007), and it is considered a key pathogenic player in several neurodegenerative and neurodevelopmental disorders (Fiskum, Murphy & Beal, 1999; Beal, 2005).”
Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis (2019, background): “Post-mitotic neurons have high demands for ATP for the maintenance of the ionic gradients across cell membranes and for the intracellular communication (Kann and Kovacs, 2007; Verkhratsky et al., 2014).”
Impaired Balance of Mitochondria Fission and Fusion in Alzheimer Disease (2009, background): “…I. Intracellular mitochondria distribution is of critical importance to neurons since the great morphological complexity and dependency on mitochondria for energy at multiple selective sites make neurons particularly sensitive to perturbations in mitochondrial distribution (Kann and Kovacs, 2007).”