Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

By T. Tammela, G. Zarkada, Elisabet Wallgard, Aino Murtomäki, S. Suchting, Maria Wirzenius, Marika Waltari, M. Hellström, T. Schomber, Reetta Peltonen and 11 more. Nature, 2008

853 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/6bea6da01afd70aeff3ca43a0c48946506b255d0

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Citations in the corpus

Signal transduction by vascular endothelial growth factor receptors. (2012, background): “However, endothelial cells engaged in active angiogenesis, such as tumor vasculature and endothelial tip cells of angiogenic sprouts in the developing retina express VEGFR3 (Tammela et al. 2008).”
CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation (2014, background): “C, Mature VEGF-C, but not pro–VEGF-C, induces the phosphorylation of Erk, Akt, and endothelial NO synthase (eNOS). eNOS detection was performed on the stripped pErk membrane, and actin detection was performed on the stripped pAkt membrane. in some instances, the angiogenic effect may be mediated via”
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting (2010, background): “Vegfr3 is also expressed in endothelial tip cells, and negatively regulated by Notc”
Basic and therapeutic aspects of angiogenesis. (2011, positive): “However, tip cells re-express VEGFR3, and its pharmacological inhibition diminishes sprouting (Tammela et al., 2008).”
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. (2009, neutral): “We observed that Jag1 inactivation in postnatal ECs leads to strongly reduced expression of VEGFR-3 at the angiogenic front in the retina (Figure 7D), which provides a direct mechanistic explanation for impaired sprouting and EC proliferation in Jag1iDEC mutants.”
Molecular control of endothelial cell behaviour during blood vessel morphogenesis (2011, positive): “However, VEGFR3 signalling also positively regulates angiogenesi”
Macrophages in skin injury and repair. (2011, neutral): “The most important dominantly stimulated by M2 macrophages, especially through the formation of VEGF (Tammela et al. 2008).”
The lymphatic vasculature in disease (2011, background): “VEGFR-3 signaling can also contribute to angiogenesis in tumors where the receptor is expressed on both tumor blood and lymphatic vessel”