Molecular control of endothelial cell behaviour during blood vessel morphogenesis

By S. P. Herbert, D. Stainier. Nature reviews. Molecular cell biology, 2011

1,021 citations recorded by the source corpus.

The vertebrate vasculature forms an extensive branched network of blood vessels that supplies tissues with nutrients and oxygen. During vascular development, coordinated control of endothelial cell behaviour at the levels of cell migration, proliferation, polarity, differentiation and cell–cell communication is critical for functional blood vessel morphogenesis. Recent data uncover elaborate transcriptional, post-transcriptional and post-translational mechanisms that fine-tune key signalling pathways (such as the vascular endothelial growth factor and Notch pathways) to control endothelial cell behaviour during blood vessel sprouting (angiogenesis). These emerging frameworks controlling angiogenesis provide unique insights into fundamental biological processes common to other systems, such as tissue branching morphogenesis, mechanotransduction and tubulogenesis.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c333282fe7d7023d1f71829d535a5191dc763fe1

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Citations in the corpus

• The Role of Macrophage Phenotype in Vascularization of Tissue Engineering Scaffolds (2014, neutral): “Blood vessel networks grow through a process of sprouting, anastomosis, andmaturation [75].”
• Ten years of anti-vascular endothelial growth factor therapy (2016, background): “…VEGFA into the vitreous humor of the eye reproduce virtually all of the aforementioned abnormalities 55 . to stimulate the proliferation of endothelial cells via the RAS–RAF–MAPK (mitogen-activated protein kinase)–ERK (extracellular signal-regulated protein kinase) signalling pathway 44 .”
• Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds (2014, neutral): “The regulation of blood vessels is a complex process involving amyriad of growth factors and signaling molecules released at precise timing and doses [30], making recapitulation with synthetic drug delivery systems an impossible task.”