Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

By Lars Jakobsson, C. Franco, Katie Bentley, Russell T Collins, B. Ponsioen, Irene M. Aspalter, I. Rosewell, M. Busse, Gavin Thurston, A. Medvinsky and 2 more. Nature Cell Biology, 2010

964 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/179e8739304c22547e455699f037915c2214cf7f

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Citations in the corpus

Basic and therapeutic aspects of angiogenesis. (2011, positive): “VEGFR1+ hematopoietic precursors or TIE2-expressing monocytes (TEMs) are located close to growing tumor vessels and release angiogenic molecules (De Palma and Naldini, 2009).”
Vascular Endothelial Cell Biology: An Update (2019, background): “The EC most sensitive to VEGF, co-determined by its higher VEGFR-2 expression relative to that of its neighboring cells [146], front becomes a tip-cell at a newly forming vascular, which guides the vessel sprout at the forefront, forming numerous filopodia that scan the environment for angiogenic cu”
Role of PFKFB3-driven glycolysis in vessel sprouting. (2013, positive): “Given that tip and stalk cells dynamically interchange positions (Jakobsson et al., 2010), we speculate that an increased level of glycolysis does not permanently convert stalk cells into a fixed tip cell phenotype, but rather that varying levels of glycolysis dynamically codetermine the fluid tip v”