Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder.

By D. Cotter, D. Mackay, Sabine Landau, R. Kerwin, I. Everall. Archives of General Psychiatry, 2001

765 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/6b5e2e5295eaf655d6c8b2e7f070258645cbf252

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Citations in the corpus

Reconsidering Anhedonia in Depression: Lessons from Translational Neuroscience (2010, background): “In MDD, both OFC and ACC have shown a variety of alterations in gross morphology, neuronal structure, function, connectivity and neurochemistry (Botteron et al., 2002; Caetano et al., 2006; Chana et al., 2003; Coryell et al., 2005; Cotter et al., 2001; Drevets et al., 2002; Fitzgerald et al., 2008; ”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “has resulted in consistent reports of a reduction in the size of neurons and number of glial cells (Ongur et al., 1998; Rajkowska et al., 1999; Cotter et al., 2001).”
Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. (2007, neutral): “4) [4-43] Episode duration, mean (SD) [range], mo 140 (130) [15-480] Total illness duration, mean (SD) [range], y 18.”
Neurocircuitry of Mood Disorders (2010, background): “…with no equivalent loss of neurons reductions in synapses or synaptic protein elevations in neuronal density and reductions in neuronal size in MDD and/or BD samples (Rajkowska et al, 1999; O ¨ ngür et al, 1998a, b; Cotter et al, 2001a, 2002; Eastwood and Harrison, 2000, 2001; Uranova et al, 2004).”
Cellular changes in the postmortem hippocampus in major depression. (2004, background): “In contrast to the increase in cell density noted in hippocampus, studies by Ongur et al (1998), Rajkowska et al (1999), Cotter et al (2001, 2002), and Bowley et al (2002) report a decrease in the density or number of glia in various regions of frontolimbic cortex and amygdala in depression.”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “One of the most consistent neuropathological findings in MDD is a reduction in the number of glia (Ongur et al, 1998; Rajkowska et al, 1999; Cotter et al, 2001, 2002; Uranova et al, 2004).”
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008, background): “For example, the common ‘‘short’’ allele of the functional 5-HTT LPR polymorphism increases the vulnerability for developing MDD within the context of stressful life events (Caspi et al. 2003).”
The Human Brain Revisited: Opportunities and Challenges in Postmortem Studies of Psychiatric Disorders (2002, background): “For example, three published studies have found evidence of reduced numbers of glial cells in regions of the frontal cortex in subjects with depression (Ongur et al. 1998; Rajkowska et al. 1999; Cotter et al. 2001).”
Depression as a microglial disease. (2015, background): “Evidence for suppressed microglial status in some depressed patients was provided by demonstrating reductions in glial cells (but not in neurons) in the subgenual anterior cingulate [143–145], as well as lower (albeit not significant statistically) microglial activation status (detected by PET imagi”
Neurobiology of emotion perception II: Implications for major psychiatric disorders. (2003, background): “…reduced density and number of glial cells in the amygdala (Bowley et al 2002), the subgenual anterior cingulate gyrus and orbitofrontal cortex (Cotter et al 2001; Drevets et al 1998; Ongur et al 1998), and the dorsolateral prefrontal cortex (Rajkowska et al 1999, 2001), and reduced neuronal…”