Depression as a microglial disease.

By R. Yirmiya, N. Rimmerman, R. Reshef. Trends in Neurosciences, 2015

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Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies (2017, background): “Evidence pointing to a role of M1 cells (including microglial cells and CNS macrophages) in MDD has accumulated (2, 65).”
The Central Nervous System and the Gut Microbiome (2016, background): “One hypothesis claims that depression, or subsets of this disorder, is a microglial disorder, as the onset of depression often follows intense inflammatory episodes in the brain or, conversely, decline in microglial function (Yirmiya et al., 2015).”
The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “, synapse pruning and neurogenesis) and are activated in many neurodegenerative and neuropsychiatric diseases, where they contribute to pathology by promoting neuroinflammation (Yirmiya et al., 2015).”