Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy.
By G. Hasler, J. W. van der Veen, Toni M. Tumonis, N. Meyers, Jun Shen, Wayne C. Drevets. Archives of General Psychiatry, 2007
837 citations recorded by the source corpus.
Subfields: Pharmacology, Plant Science, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/920f9d7a41ab15d870f172f25879e295aec25406
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In Pharmacology
- R. Duman
- G. Sanacora
- Joseph L. Price
- Michael T. Treadway
- David H. Zald
- Maura L. Furey
- Wayne C. Drevets
- R. Spanagel
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Reconsidering Anhedonia in Depression: Lessons from Translational Neuroscience (2010, background): “Recent evidence suggests that depression may be associated with reduced glutamate function in prefrontal regions including the ACC (Hasler et al., 2007), especially in individuals with anhedonic symptoms (Walter et al., 2009).”
- Towards a glutamate hypothesis of depression (2011, background): “A large majority of studies have provided evidence of reduced glutamate metabolite levels in the frontal cortex and cingulate regions of patients with major depressive disorder in the midst of a current depressive episode (Auer et al., 2000; Michael et al., 2003a, 2003b; Hasler et al., 2007).”
- Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008, background): “Early studies reported that GABA concentrations were abnormally decreased in the plasma and cerebrospinal fluid (CSF) in MDD subjects (reviewed in Hasler et al. 2007).”
- Alcoholism: a systems approach from molecular physiology to addictive behavior. (2009, background): “Measurements of central glutamate have only recently begun to appear in the literature (179, 430, 544) (Fig.”
- Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments (2019, background): “Brain MRS studies also report reduced GABA levels in cortical brain regions of depressed patients, and normalization of GABA with remission (Godfrey et al., 2018; Hasler et al., 2005; Hasler et al., 2007; Price et al., 2009; Sanacora et al., 1999; Schur et al., 2016).”