Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

By H. Chuang, E. D. Prescott, H. Kong, S. Shields, S. Jordt, A. Basbaum, M. Chao, D. Julius. Nature, 2001

1,318 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/6acdd001647d784be6b9f66a87dfeff95346d5d5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Julius
2. Clifford J. Woolf
3. R. Ji
4. D. Clapham
5. Ardem Patapoutian
6. A. Basbaum
7. M. Chao
8. T. Balla

In Physiology

1. Clifford J. Woolf
2. R. Ji
3. D. Julius
4. Ardem Patapoutian
5. S. Jordt
6. D. Bautista
7. A. Basbaum
8. N. Bunnett

In Sensory Systems

1. D. Julius
2. Ardem Patapoutian
3. Clifford J. Woolf
4. B. Nilius
5. D. Clapham
6. G. Owsianik
7. D. Bautista
8. T. Voets

Citations in the corpus

• An introduction to TRP channels. (2006, background): “PIP2 appears to bind TRPV1 directly, causing channel inhibition that is relieved by PLC-catalyzed PIP2 hydrolysis (25, 76).”
• Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. (2009, background): “Signaling via TRP channels has been observed for many GPCRs in DRG neurons, including the histamine and bradykinin receptors (Chuang et al., 2001; Shim et al., 2007).”
• Neurotrophins and their receptors: A convergence point for many signalling pathways (2003, background): “In contrast to NGF-injected normal mice, which showed a marked decrease in paw withdrawal latency in response to a thermal stimulus, injection of NGF into TRPV1-deficient mice did not produce any sensitizatio”
• Transient receptor potential cation channels in disease. (2007, background): “The TRP Channel Family and Diseases 172 A. Introductory remarks 172 B. Dysfunctions in TRP channelopathies 173 C. TRPs and pain 182 D. TRP channels in systemic diseases 188 E. TRPs and aging 199 F. TRPs and cancer 199 G. Candidate genes 200 H. Lessons from knockout and transgenic mice 201 I. PIP2-TR”
• TRP channels and pain. (2013, background): “…of the channel’s C-terminal tail interacts with the negatively charged phospholipid head groups on the inner leaflet of the plasma membrane (Chuang et al. 2001, Prescott & Julius 2003, Ufret-Vincenty et al. 2011), reminiscent of well-studied interactions between PIP2 and cytoplasm-facing…”
• The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept (2007, background): “; bradykinin (an endogenous inflammatory peptide that causes hyperalgesia”
• Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. (2004, background): “Hyperalgesia to heat is thought to involve sensi- tization of TRPV1 (Chuang et al., 2001; Tominaga et that mustard oil activates TRPA1 and perhaps another unidentified ion channel.al., 2001).”
• Cellular and Molecular Mechanisms of Pain (2009, neutral): “This results in functional potentiation of target proteins at the peripheral nociceptor terminal, most notably TRPV1, leading to a rapid change in cellular and behavioral heat sensitivity (Chuang et al., 2001).”
• Neurotrophin-regulated signalling pathways (2006, background): “…TRP channel VR1 (the capsaicin receptor) appears to be repressed by PtdIns (4,5)P 2 , so PLC-g1-stimulated depletion of PtdIns (4,5)P 2 , as a result of TrkA activation, results in hypersensitization of this channel to thermal and mechanical stimuli (Chuang et al. 2001; Prescott & Julius 2003).”