Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.
By Qin Liu, Zongxiang Tang, L. Surdenikova, Seungil Kim, Kush N. Patel, Andrew Y. Kim, F. Ru, Y. Guan, H. Weng, Yixun Geng and 5 more. Cell, 2009
779 citations recorded by the source corpus.
Subfields: Dermatology, Rheumatology, Sensory Systems
View Paper: https://www.semanticscholar.org/paper/33976351c24ef6de484024ceb0dad2c75f7b56a6
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In Sensory Systems
Citations in the corpus
- Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch (2017, positive): “Earlier studies have shown that pruritogens, such as histamine and theMrgprA3 agonist chloroquine, are differentially dependent on the transient receptor potential (TRP) channels TRPV1 and TRPA1 for their activity via extracellular calcium influx (Liu et al., 2009; Wilson et al., 2013b).”
- Identification of a mast cell specific receptor crucial for pseudo-allergic drug reactions (2014, methodology): “PAMP(9–20)was customsynthesized and purified to$98% byGenscript.”
- TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch (2011, positive): “1) and are inhibited by ruthenium red, which abolishes CQ-evoked signaling 16 .”