Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

By Toshimasa Yamauchi, J. Kamon, Y. Minokoshi, Yoichi M. Ito, H. Waki, S. Uchida, S. Yamashita, M. Noda, Shunbun Kita, K. Ueki and 10 more. Nature Medicine, 2002

4,390 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/6a6818950eced9e1e4f257f4e0b4317beadc1f7f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. P. Scherer
2. H. Fang
3. R. L. Judd
4. Barry J. Goldstein
5. Rosario Scalia
6. D. Hardie
7. Sushil Kumar Jain
8. Herbert Tilg

In Molecular Biology

1. D. Hardie
2. G. Steinberg
3. Bruce E. Kemp
4. David Carling
5. S. Hawley
6. J. Scott
7. Ralph DeFronzo
8. Barry J. Goldstein

In Physiology

1. P. Scherer
2. D. Hardie
3. Sushil Kumar Jain
4. H. Fang
5. R. L. Judd
6. G. Steinberg
7. Mitchell A. Lazar
8. A. Achari

Citations in the corpus

• PPARs and the complex journey to obesity (2004, background): “This pathway is mediated by adiponectin receptors and downstream AMP-activated protein kinas”
• Adiponectin and adiponectin receptors. (2005, background): “Our data may provide a novel paradigm that an adipocyte-derived hormone activates AMPK, thereby directly regulating glucose metabolism and insulin sensitivity in vitro and in vivo (51) (Fig.”
• TNF-α and adipocyte biology (2007, background): “Adiponectin enhances insulin sensitivity and improves the serum lipid profile through AMPK activation and increased FA oxidation [106,107].”
• Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. (2010, background): “Similar to leptin, adiponectin enhances insulin sensitivity through activation of adenosine monophosphate protein kinase (Yamauchi et al., 2002).”
• Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Several mechanisms for adiponectin’s metabolic effects have been described (Berg et al. 2001; Yamauchi et al. 2002).”
• AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. (2005, background): “In liver, AMPK activation is necessary for the effects on inhibition of PEPCK and glucose 6 phosphatase expression and hepatic glucose production (Yamauchi et al., 2002).”
• GENeration (2015, neutral): “These preliminary design criteria would consider definition of array storage conventions within the ILLIAC IV processing element memories, and specialized storage schemesand disk mapping criteria for internal file communications and external files used in intermodular communication.”
• Adipokines in inflammation and metabolic disease (2011, background): “The beneficial effects of adiponectin on insulin sensitivity seem to be mediated in part by its ability to activate AMP-activated protein kinase (AMPK) in skeletal muscle and live”