AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

By B. Kahn, T. Alquier, David Carling, D. Hardie. Cell Metabolism, 2005

2,924 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/61080cf356eb8b02c8ff73bd70ef610357c8bd8f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. David M. Sabatini
2. R. Shaw
3. B. K. Pedersen
4. Herbert Tilg
5. T. Borody
6. A. Khoruts
7. Jianping Ye
8. Gerald I. Shulman

In Molecular Biology

1. David M. Sabatini
2. R. Shaw
3. D. Hardie
4. K. Guan
5. M. Laplante
6. Craig B. Thompson
7. J. Blenis
8. G. Steinberg

In Surgery

1. R. Shaw
2. D. Hardie
3. David M. Sabatini
4. Michael Pollak
5. K. Guan
6. G. Steinberg
7. Bruce E. Kemp
8. Craig B. Thompson

Citations in the corpus

• Muscles and their myokines (2011, background): “This effect may to some extent be mediated by AMPK (Kahn et al., 2005; Carey et al., 2006).”
• Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies (2015, background): “The effect of leptin on insulin sensitivity in the liver and skeletal muscle is mediated through phosphorylation and activation of AMPK and inhibition of the activity of acetylCoA carboxylase.(259,260) Leptin-induced stimulation of the PI3K signaling pathway appears to be important for the regulatio”
• AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. (2011, background): “…balance in a cell-autonomous manner, AMPK is also modulated by numerous hormones and/or cytokines that regulate energy balance at the whole body level, including leptin, adiponectin, and ghrelin (Kahn et al. 2005); cannabinoids (Kola et al. 2006); and even thyroid hormones (Lopez et al. 2010).”
• Adipocytokines: mediators linking adipose tissue, inflammation and immunity (2006, background): “AMPK is an evolutionarily conserved sensor of the energy status of a cell, and it has a crucial role in controlling the systemic energy balance by regulating food intake, body weight, and glucose and lipid homeo-stasi”
• Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “Several other studies have described that IL-6 can increase intramyocellular (58-60) or whole body (61) fatty acid oxidation via AMPK activation (58, 62).”
• Role of myokines in exercise and metabolism. (2007, background): “AMPK activation stimulates fatty acid oxidation and increases glucose uptake (32).”
• An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. (2007, positive): “AMPK is activated in response to decreased energy or glucose levels, which are consequences of DR [6], and in specific cases, by DR itself [7].”