Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex.

By Nora D. Volkow, J. S. Fowler. Cerebral Cortex, 2000

1,255 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/697a10f145cb1a9aa3984fe5538f0cb720799984

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Citations in the corpus

Orbitofrontal cortex and its contribution to decision-making. (2007, background): “An extensive literature implicates the OFC in CLINICAL IMPLICATIONS OFC dysfunction is associated with disorders involving compulsive behavior (Volkow & Fowler 2000) such as obsessivecompulsive disorder, substance abuse, eating disorders, obesity and pathological gambling.”
How can drug addiction help us understand obesity? (2005, background): “For example, in cocaine-addicted subjects, imaging studies show that changes in dopamine brain activity (reductions in dopamine D2 receptors and in dopamine release in striatum) are associated with disruption in the activity of the prefrontal corte”
Loss of willpower: Abnormal neural mechanisms of impulse control and decision making in addiction (2005, background): “On the other hand the supracallosal sector of the anterior cingulate cortex is necessary for the feeling of craving (related to the action of seeking, obtaining, and consuming the drug).”
Hypersexual Disorder: A Proposed Diagnosis for DSM-V (2010, background): “…procedures as well as sophisticated neuropsychological testing in impulsivity disorders , including substance abuse disorders and behavioral addictions (Bechara, 2005; Cavedini, Riboldi, Keller, D'Annucci , & Bellodi, 2002; London, Ernst, Grant, Bonson, & Weinstein, 2000; Volkow & Fowler, 2000).”
The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies. (2004, background): “This has led us to speculate that OFC and CG hypermetabolism could trigger compulsive drug intake just as hypermetabolism of OFC and CG contributes to compulsive behaviors in patients with obsessive compulsive disorders (Volkow and Fowler, 2000).”
Decision-making and addiction (part II): myopia for the future or hypersensitivity to reward? (2002, background): “This suggests that when craving and thoughts related to drug reward activate the prefrontal and insular cortices [31,38,55,56], there is induction of strong somatic states.”
Addiction: Beyond dopamine reward circuitry (2011, background): “Because OFC, CG, and DLPFC are involved with salience attribution, inhibitory control/emotion regulation, and decision making, we had postulated that their improper regulation by DA in addicted subjects could underlie the enhanced motivational value of drugs in their behavior and loss of control ove”
Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task (2003, background): “Other studies have also shown that cocaine abuse is related to a disruption in the striato-thalamo-orbitofrontal circuit (Volkow et al., 1993; Volkow and Fowler, 2000; Goldstein et al., 2001).”
The Brain on Drugs: From Reward to Addiction. (2015, background): “The ACC and OFC are necessary for self-control and for processing salience attribution, and their disruption is associated with a propensity for impulsive and compulsive behaviors (Volkow and Fowler, 2000).”
Drug Addiction, Dysregulation of Reward, and Allostasis (2001, background): “Activation of these regions as visualized by imaging techniques in drug abuse during intense craving (Volkow and Fowler 2000) is the same as those visualized in obsessive-compulsive disorder (Baxter et al.”
Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving. (2004, neutral): “175–176), conditioned drug seeking (10, 42), and craving (29, 30, 33).”
Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients. (2002, neutral): “Functional abnormalities in cocaine-dependent (COC) patients have been observed in the orbitofrontal cortex (OFC), the insula, and other limbic-related regions (London et al 2000; Strickland et al 1993; Volkow and Fowler 2000; Volkow et al 1991; Holman et al 1991).”
Addiction related alteration in resting-state brain connectivity (2010, positive): “The OFC is a major area of motivation, drive, and salience evaluation, which is impaired in drug addicts and plays an important role in the output of compulsive drug-seeking behaviors (Volkow and Fowler, 2000).”
Integrating psychological and neurobiological considerations regarding the development and maintenance of specific Internet-use disorders: An Interaction of Person-Affect-Cognition-Execution (I-PACE) model. (2016, positive): “…ther Internet-use disorders (e.g., Brand et al., 2016) may reflect maladaptive interaction of cue-reactivity/craving and reduced refrontal/executive functioning, as suggested for substance addicions (Goldstein and Volkow, 2011; Koob and Volkow, 2010; olkow and Fowler, 2000; Volkow et al., 2002).”