Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients.

By T. Franklin, P. Acton, J. Maldjian, J. Gray, Jason R. Croft, C. Dackis, C. O'brien, Anna Rose Childress. Biological Psychiatry, 2002

600 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Epidemiology, Toxicology

View Paper: https://www.semanticscholar.org/paper/de764fd8d7ad4984e536f3e87fd8a3ee30e29d64

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In Cellular and Molecular Neuroscience

In Epidemiology

In Toxicology

Nora D. Volkow

Citations in the corpus

Disorders of compulsivity: a common bias towards learning habits (2014, unknown): “Abstinent stimulant use disorder subjects have decreased medial orbitofrontal cortex volumes (21), with lower volumes associated with impaired decisions in a modified gambling task (22).”
Executive Dysfunction in Cocaine Addiction: Evidence for Discordant Frontal, Cingulate, and Cerebellar Activity (2004, background): “Repeated use of cocaine is associated with structural (Franklin et al., 2002; Matochik et al., 2003) and metabolic (Ernst et al.”
The addicted human brain: insights from imaging studies. (2003, background): “Also, a recent imaging study reported structural changes in the OFC of cocaine-addicted subjects (57), and the possibility was discussed that this might have preceded drug use and might have made these subjects more vulnerable to addiction.”
Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective (2005, background): “1 ), including the VMPC, anterior cingulate, insular corte”
Mesocorticolimbic Circuits are Impaired in Chronic Cocaine Users as Demonstrated by Resting State Functional Connectivity (2010, unknown): “Neuroimaging studies in drug dependent individuals have revealed significant alterations in brain structure (Franklin et al., 2002; Matochik et al., 2003), neurotransmitters (Goldstein and Volkow, 2002), metabolism (Volkow et al.”
Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. (2002, background): “For example, frontal lobe volume losses have been identified in cocaine-dependent subjects (5, 6), alcoholic subjects (7–9), and heroin-dependent subjects (5).”
The Antisocial Brain: Psychopathy Matters: A Structural MRI Investigation of Antisocial Male Violent Offenders (2012, background): “Most studies have included offenders with comorbid substance use disorders (SUDs)(39-45,49-53,56,57,59) that are also independently associated with GM volume decrements in regions of interest such as the orbitofrontal cortex.(48,60) These studies have attempted to control for the presence of SUDs ei”
Dopamine in drug abuse and addiction: results from imaging studies and treatment implications (2004, background): “62 Recently, imaging studies using MRI also documented decreased gray matter in the OFC of cocaine abusers indicating that the abnormalities are not only functional but also morphological”
Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task (2003, result): “In addition to PET studies, investigations of brain morphology show smaller gray matter volumes in regions such as the ventromedial orbitofrontal, anterior cingulate, anteroventral insular, superior temporal cortices (Franklin et al., 2002), and the prefrontal cortex as a whole in cocaine abusers in”
Drug Addiction as a Pathology of Staged Neuroplasticity (2008, background): “A reduction in frontal cortical neurons has also been reported in drug-free cocaine addicts (Franklin et al, 2002), but it is unknown whether these functional and anatomical indications of hypofrontality were vulnerability factors present before cocaine use or the effects of chronic stimulant use.”