Drug Addiction, Dysregulation of Reward, and Allostasis

By G. Koob, M. Le Moal. Neuropsychopharmacology, 2001

2,844 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aafa5e522e876063a47aa30ad7fb175edb42d63a

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. (2005, background): “By controlling all the mechanisms simultaneously, the brain can enforce its command and incorporate influential factors such as experience, memories, anticipation, and re-evaluation of needs in anticipation of physiological requirements [9].”
The genetics of addictions: uncovering the genes (2005, background): “Studies on drug-exposed animals indicate that long-lasting physiological changes take place that are associated with changes in the expression of stress-related gene”
Mechanisms and psychological explanation (2007, background): “Generally, chronic drug use compromises the integrity of brain reward function and organization, resulting in long-term structural, functional, and organizational neuroadaptive changes in the mesolimbic system (Franken, 2003; Koob & Le Moal, 1997, 2001 ).”
Stress, dysregulation of drug reward pathways, and the transition to drug dependence. (2007, background): “An allostatic view of drug addiction thus provides a heuristic model with which to explore residual changes following drug binges that contribute to vulnerability to relapse (1, 15, 71).”
Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. (2002, background): “These changes are likely to involve disruption of frontal cortical circuits and neurotransmitters that include dopamine, serotonin, and corticotropin-releasing factor (26).”
Alcoholism: allostasis and beyond. (2003, background): “This homeostatic dysregulation has been expanded conceptually to the realm of allostasis, the ability to attain stability but at an altered, potentially pathologic set point (Koob and Le Moal, 2001).”
An Evolutionary Framework to Understand Foraging, Wanting, and Desire: The Neuropsychology of the SEEKING System (2012, background): “This eventually shifts drug taking into an attempt to simply reduce negative affect and feel psychologically “normal” (Koob & LeMoal, 2001).”
The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making (2010, background): “negative reinforcement. More recent models ( Koob and Le Moal 2001 ) have posited that chronic drug use leads to a change in reward set-point, such the individual requires increasing quantities of the drug in order to achieve the same effects, and also obtains less reward from more adaptive reinforc”