The Brain on Drugs: From Reward to Addiction.

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The Neuroscience of Drug Reward and Addiction. (2019, neutral): “The amygdala/hippocampus (mediating emotions, mood, and stress reactivity) and the insula (responsible for integrating and translating in-teroceptive signals) are also relevant as targets for addiction treatment (246, 339).”
Neurobiologic Advances from the Brain Disease Model of Addiction (2016, background): “These regions also regulate the firing of dopamine cells and the release of dopamine.(19) Box 2.”
Role of the Prefrontal Cortex in Pain Processing (2018, background): “Such alterations may involve downregulation of striatal D2 receptors as a result of use of addictive drugs or substances [208], and could lead to increased corticostriatal input.”