How can drug addiction help us understand obesity?

By Nora D. Volkow, R. Wise. Nature Neuroscience, 2005

1,091 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/12408267e7ad8fde55c42713d983d2487084c7a8

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Citations in the corpus

Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology (2008, background): “…concentrations (involves DA increases), whereas drugs activate this same circuitry via their pharmacological effects (via direct effects on DA cells or indirectly through neurotransmitters that modulate DA cells such as opiates, nicotine, g-aminobutyric acid or cannabinoids ; Volkow & Wise 2005).”
Stress, eating and the reward system. (2007, background): “While drugs of abuse activate the reward pathway in a rather direct pharmacological way, palatable food acts via both, fast sensory inputs as well as slower post-ingestive processes such as increased blood glucose and adiposity and possibly gut signals [108].”
Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. (2008, background): “(natural and artificial) stimulate some of the same neural systems (Hoebel, 1985; Hernandez and Hoebel, 1988; Kelley et al., 2002; Le Magnen, 1990; Volkow and Wise, 2005; Wise, 1989).”
Reward Mechanisms in Obesity: New Insights and Future Directions (2011, background): “In fact, because of the many similarities between overeating in obesity and excessive drug use in addiction (Volkow and Wise, 2005), it has been argued that obesity should be considered as a brain disorder and included as a diagnostic category in the forthcoming fifth edition of the Diagnostic and…”
A Randomized, Phase 3 Trial of Naltrexone SR/Bupropion SR on Weight and Obesity-related Risk Factors (COR-II) (2013, background): “Dysregulation of CNS reward pathways, in a manner similar to what is observed with addictive disorders, may contribute to the pathophysiology of obesity (22).”
Widespread reward-system activation in obese women in response to pictures of high-calorie foods (2008, neutral): “031 Recently, there has been increased interest in potential parallels between drug addiction and obesity (Del Parigi et al., 2003; Pelchat, 2002; Volkow and Wise, 2005).”
Hedonic hunger: a new dimension of appetite? (2007, methodology): “Because food reward and drug reward appear to have common neural pathways [27,28], addiction models have been used to investigate the hedonic properties of palatable food.”
Preliminary validation of the Yale Food Addiction Scale. (2009, background): “Unlike drugs, the importance of sensory processes in food consumption (Volkow & Wang, 2005) may result in food advertising having an increased tendency to trigger overconsumption.”
Addiction-like reward dysfunction and compulsive eating in obese rats: Role for dopamine D2 receptors (2010, background): “Discussion Ease of access to palatable high-fat food is considered to be an important environmental risk factor for obesit”
The debate over dopamine’s role in reward: the case for incentive salience (2007, background): “After all, many pleasant rewards activate mesolimbic dopamine systems, ranging from food, sex, and drugs to social and cognitive rewards (Aragona et al. 2006; Becker et al. 2001; Everitt and Robbins 2005; Fiorino et al. 1997; Koob and Le Moal 2006; Roitman et al. 2004; Small et al. 2003; Thut et al.”
fMRI Reactivity to High-Calorie Food Pictures Predicts Short- and Long-Term Outcome in a Weight-Loss Program (2012, background): “to the proposed circuitry for drugs of abuse (Del Parigi et al., 2003; Volkow and Wise, 2005; Volkow et al., 2008).”
Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction (2008, background): “…is the observation of reductions in dopamine D 2 receptors in the dorsal striatum in abstinent alcoholics, cocaine, heroin and methamphetamine addicts (Volkow & Wise 2005) and also following chronic, but not acute, cocaine self-administration in monkeys (Moore et al. 1998; Nader et al. 2002).”
Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals (2007, background): “…cf. Nieuwenhuys et al., 1991), a part of the habit learning system, which has previously been linked to a lowered DA D2 receptor availability in obese (Wang et al., 2001) and drug-addicted individuals (Volkow et al., 1996, 1997; Volkow and Wise, 2005; Heinz et al., 2004; Martinez et al., 2004).”