Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells.

By T. Kondo, M. Raff. 2000

904 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Molecular Biology

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Citations in the corpus

Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia–Ischemia (2002, background): “Because OL progenitors were recently shown to be multipotent under some in vitro conditions ( Kondo and Raff, 2000 ), the susceptibility of late OL progenitors to H-I may have important implications for brain injury and repair in both the developing and adult nervous system.”
Origin of Oligodendrocytes in the Subventricular Zone of the Adult Brain (2006, background): “However , committed glial pre - cursors , like the optic nerve O - 2A progen - itor , can be manipulated to also generate neurons ( Kondo and Raff , 2000 ) .”
Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. (2009, background): “Indeed, OLPs in vitro can acquire stem cell properties through sequential exposure to BMP, PDGF, and EGF/FGF (Kondo and Raff, 2000).”
The Adult Substantia Nigra Contains Progenitor Cells with Neurogenic Potential (2002, background): “Another important point is that in vivo proliferating SN progenitor cells could differentiate into neurons immediately after isolation, without short-term exposure to high doses of FGF2 which in previous in vitro studies led to neuronal differentiation of glial-restricted precursors (Palmer et al., ”
The development of neural stem cells (2001, background): “Optic nerve O2A progenitor cells, which normally produce solely glia, can be converted in vitro into multipotent, neurosphere-generating stem cell”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “Neural precursor cells have been found in a large number of Adult neurogenesis and cellular brain repair U. Shivraj Sohur and others 1481 brain regions, including white-matter tracts (Palmer et al. 1999; Kondo & Raff 2000).”
For the long run: maintaining germinal niches in the adult brain. (2004, background): “…their adhesion. is also supported by reports indicating that early oligodendrocyte precursors can be induced to behave asAnother set of molecules associated with astrocytes in the neurogenic regions is the Eph/ephrin family of stem cells in vitro (Kondo and Raff, 2000; Nunes et al., 2003).”
NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. (2010, background): “Proliferating NG2 Cells in ALS Spinal CordDifferentiate into OLs, but Not Astrocytes or Neurons NG2 cells can develop into most major CNS cell types in vitro when exposed to different growth factors (Kondo and Raff, 2000), suggesting that environmental cues can influence the”