NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration.

By Shin H. Kang, M. Fukaya, Jason K Yang, Jeffrey D. Rothstein, D. Bergles. Neuron, 2010

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In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer’s disease model (2013, background): “NeuroD1 Reprograms NG2 Cells into Glutamatergic and GABAergic Neurons NG2 cells are the major proliferative glial cells in the adult brain under normal physiological conditions (Buffo et al., 2008; Kang et al., 2010).”
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics (2011, neutral): “A study using Z/EG mice for lineage tracing has shown that NG2+ progenitors give rise to oligodendrocytes, but not new neurons, in the adult dentate gyrus (Kang et al., 2010).”
Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013, background): “…of an OL in the cortex because axons in gray matter are not all aligned with one another as they are in white matter (Murtie et al., 2007; Vinet et al., 2010) and is consistent with the myelinating morphology previously reported for adult-born cortical OLs (Kang et al., 2010; Zhu et al., 2011).”