The development of neural stem cells

By Sally Temple. Nature, 2001

1,570 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6c793a8a6c1fd76503024458de4a28d3dda4cbc2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

In Molecular Biology

Citations in the corpus

REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. (2005, background): “Although ES and neural stem cells each have the capacity to self renew, the differentiation capacity of the latter and other neural progenitors is restricted to a neural lineage ( Temple, 2001 ).”
Stem cell niche: structure and function. (2005, background): “…y. ANRV255-CB21-25 ARI 8 September 2005 17:11 subgranular zone (SGZ) of the hippocampus region are the primary and well-characterized germinal regions in which NSCs reside and support neurogenesis in the adult brain (Doetsch 1999, 2003, Lois & Alvarez-Buylla 1993, Palmer et al. 1997, Temple 2001).”
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation (2004, background): “As neural stem cells, radial glia give rise to neurons first and glial cells later (Fujita, 1964; McConnell, 1995; Temple, 2001).”
The glial identity of neural stem cells (2003, background): “Both regions harbor neural stem cells that can be cultured in vitro in the presence of growth factors such as epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF”
Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. (2002, background): “Many lines of recent evidence have re-The University of Tokyo Graduate School of Medicine vealed, however, that progenitors with the ability to produce new neurons and glia remain in the adult CNS. In7-3-1 Hongo Bunkyo-ku, Tokyo 113-0033 particular, neural stem cells defined with the characteristics”
Cancer stem cells in nervous system tumors (2004, background): “…that multipotential, self-renewing NSCs exist throughout life in the adult mammalian brain has only re-emerged in the past decade (Gage, 2000; Temple, 2001; Gage, 2002), reflecting a rediscovery of 1960s evidence that suggested that neurogenesis was occurring in the adult brain (Gross, 2000).”
An essential switch in subunit composition of a chromatin remodeling complex during neural development. (2007, background): “The array of specialized neuronal and glial cell-types that characterize the adult central nervous system (CNS) originate from multipotent neuroepithelial (NE) precursor cells that line the ventricles of the developing spinal cord and brain (Gage, 2000; Roegiers and Jan, 2004; Temple, 2001).”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “In contrast, upon transplantation into the SVZ, RMS or SGZ, cultured neural stem cells derived from nonneurogenic regions can generate neurons appropriate to the region (Suhonen et al. 1996; Shihabuddin et al. 2000; reviewed in Temple 2001).”
Neurogenesis in the adult brain: new strategies for central nervous system diseases. (2004, background): “During development of the mammalian CNS, neurons and glia arise from multipotent neural stem cells in a stereotyped sequence in which neurons are generated first, primarily during the embryonic period, followed by glia, the majority of which differentiate after most neurons are born (13, 14).”
Specification of motoneurons from human embryonic stem cells (2005, background): “From the standpoint of both stem cell biology and developmental biology, it is not difficult to understand why brain-derived neuroepithelial cells do not normally generate projection neurons of a different regional identity, particularly after expansio”
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics (2011, neutral): “Neural stem cells are defined by their ability to self-renew and generate different neural cell types, such as neurons, astrocytes, and oligodendrocytes (Gage, 2000; Temple, 2001).”
Developmental genetics of vertebrate glial–cell specification (2010, background): “At these early stages, neuroepithelial cells are insensitive to cytokine”
The endocannabinoid system drives neural progenitor proliferation (2005, neutral): “Growth factors, such as epidermal and fibroblast-derived growth factor (EGF, FGF-2), act as key regulators of NP cell proliferation and differentiation (13, 14).”
Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. (2006, background): “Shortly after birth, this embryonic niche begins a transformation into the postnatal neural stem cell niche in the subventricular zone (SVZ) of the lateral ventricles (LVs) (reviewed in Temple, 2001; Tramontin et al., 2003).”