The Pezcoller lecture: cancer cell cycles revisited.

By C. Sherr. Cancer Research, 2000

1,344 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/68aae7d8dc1f7e87721535ddf8755534f41f6bc1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Aviv Regev
2. D. Louis
3. F. Furnari
4. Jiyong Liang
5. K. Orford
6. R. Kumari
7. R. DePinho
8. P. Jat

Citations in the corpus

• Ink4a/Arf expression is a biomarker of aging. (2004, background): “are principal regulators of the mammalian cell cycle (25).”
• Minireview: Cyclin D1: normal and abnormal functions. (2004, background): “restriction point leads to DNA synthesis (30, 31) (Fig.”
• The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition (2007, background): “The regulation of G1- to S-phase transition is governed by the concerted action of cyclin-dependent kinases (Cdks) and their regulatory cyclin subunits (reviewed in Sherr, 2000; Malumbres and Barbacid, 2001).”
• Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation (2008, background): “This is consistent with the concept that early G1 phase is the main window during which extracellular stimuli (for example, growth factors and morphogens ) can affect cell-fate decisions, particularly the decision to enter the cell cycle and/or commit to differentiatio”
• Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021, background): “…bind and inactivate CDK4 and CDK6, thereby inducing a cell cycle arrest only during G0/G1 phase (Wade Harper et al., 1993; Pavletich, 1999; Sherr, 2000). p21WAF1/CIP1 can also be activated by p53 independent mechanisms by other stimulators such as nuclear receptors including androgen,…”
• HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation (2001, background): “MDM2 is feedback regulated by p53 and by the expression of ARF protein (p14 in humans and p19 in mice), which is encoded by the Ink4A locu”
• The Concept of Synthetic Lethality in the Context of Anticancer Therapy (2005, background): “For example, RB1 inactivation, as described above, leads to increased E2F activity, which can stimulate S-phase entry but can also promote p53-dependent apoptosi”
• Rescuing the function of mutant p53 (2001, background): “, and second, treatment often fails because the cancer inactivates tumour-suppressor pathways (reviewed in Ref”
• The regulation of INK4/ARF in cancer and aging. (2006, unknown): “Evidence suggests that INK4a/ARF expression increases at an early stage of tumorigenesis (reviewed in Sherr, 2000), but the precise stimuli relevant to cancer that induce the expression of the locus are unknown.”
• Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression (2003, background): “PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model.”
• Malignant glioma: genetics and biology of a grave matter. (2001, background): “…the CKI GENES & DEVELOPMENT 1319 p27Kip1 (hereafter referred to as p27), in the timing mechanism governing progenitor cell commitment. p27 regulates progression from G1 to S phase by directly inhibiting cyclin E–dependent kinases and indirectly inhibiting cyclin D–dependent kinases (Sherr 2000).”