The Concept of Synthetic Lethality in the Context of Anticancer Therapy
By W. Kaelin. Nature Reviews. Cancer, 2005
1,445 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/9aa1e3325be34d33a1f8e0864c7b2ff9c45bff0d
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In Molecular Biology
- Jill P. Mesirov
- Eric S. Lander
- C. Lord
- Alan Ashworth
- Pablo Tamayo
- Andrew K. Joe
- David M. Sabatini
- R. Brough
Citations in the corpus
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 (2009, background): “(2) Feature ranking: after pre-processing, each shRNA was assigned a ‘differ-”
- Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors (2009, positive): “Synthetic lethal approaches to cancer treatment have the potential to deliver relatively large therapeutic windows and significant patient benefit (Kaelin, 2005).”
- The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability (2006, background): “The concept of synthetic lethality applies when the mutation of two genes causes death, while mutation of either gene alone is viable (Hartwell, 1997; Kaelin, 2005).”
- Targeting cancer with small molecule kinase inhibitors (2009, neutral): “For a second class of kinase target, inhibition of the kinase results in a synthetic-lethal phenotype when paired with another non-lethal mutation in the particular pathology of the tumour cel”
- Oncogene addiction. (2008, background): “The concept of ‘‘synthetic lethality,’’ derived from studies in lower organisms, may also be relevant (14).”
- Synergistic drug combinations improve therapeutic selectivity (2009, positive): “Synergistic combinations of two or more agents can overcome toxicity and other side effects associated with high doses of single drugs by countering biological compensation, allowing reduced dosage of each compound or accessing context-specific multitarget mechanism”