Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins.

By M. Brand, C. Affourtit, Telma C Esteves, K. Green, A. J. Lambert, Satomi Miwa, Julian L. Pakay, Nadeene Parker. Free Radical Biology & Medicine, 2004

1,054 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/670c85d9b7fe1c6008ceece49fde0111e25a4e9a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. M. Brand
2. W. Buttemer
3. M. Murphy
4. R. Pamplona
5. Orian Shirihai
6. A. Hulbert
7. R. Buffenstein
8. M. Jackson

In Physiology

1. M. Brand
2. W. Buttemer
3. M. Murphy
4. R. Pamplona
5. M. Jackson
6. S. Powers
7. A. Hulbert
8. R. Buffenstein

Citations in the corpus

• Mitochondrial proton and electron leaks (2010, background): “They may, however, catalyse proton leak when appropriately activated [24].”
• How mitochondria produce reactive oxygen species (2008, background): “The generation of O 2 •− by both modes 1 and 2 will be decreased by mild uncoupling, perhaps suggesting that the physiological function of uncoupling proteins-2 and -3 is to modulate mitochondrial O 2 •− production [118].”
• Oxidative stress in marine environments: biochemistry and physiological ecology. (2006, background): “The loss of energy and the production of ROS via H+ leakage can also be regulated by specific uncoupling proteins, which themselves are upregulated by the production of ROS (25).”
• Oxidative stress in angiogenesis and vascular disease. (2014, background): “In mitochondria, more than 95% of oxygen consumed by cells is used to yield water molecules through redox reactions.(14)”
• Life and death: metabolic rate, membrane composition, and life span of animals. (2007, background): “If the different MLSP of birds with different life histories is partly due to variation in mitochondrial free radical production, then comparative studies focusing on UCP expression and function in birds, particularly the potential for superoxides to stimulate UCP2 and UCP3 expression (38), might yi”
• Cellular and molecular mechanisms of mitochondrial function (2012, neutral): “23”
• Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production (2008, background): “mitochondrial production of ROS (52, 53) acting to pro-”
• Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life (2006, background): “Formation of 4-hydroxynonenal or O2c 2 within mitochondria seems to activate uncoupling proteins, which should then decrease the membrane potential and limit O2c 2 formation (Brand et al., 2004).”
• Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure (2013, background): “This lack of toxicity could be explained by the association between mitochondrial membrane potential and escape of electrons from the electron transport chain to generate ROS (Brand et al., 2004).”
• The sites and topology of mitochondrial superoxide production (2010, background): “…involved in ROS generation have been defined in isolated mammalian mitochondria using electron transport chain inhibitors (Andreyev et al., 2005; Brand et al., 2004; Jezek and Hlavata, 2005; Murphy, 2009; Raha and Robinson, 2000; Turrens, 2003), but we lack reliable measurements of their rates…”
• Superoxide Flashes in Single Mitochondria (2008, neutral): “increased electron flow may cause dissipation of mitochondrial membrane potential (DJm) and reduce ROS generation ( Brand et al., 2004 ).”
• Oxidative stress, mitochondrial damage and neurodegenerative diseases (2013, background): “Furthermore, the products of sugar, protein, and lipid oxidation can cause secondary damage to proteins, which may lose catalytic function and undergo selective degradation [38] .”